摘要
应用~3H-TdR掺入法和间接免疫荧光法测定21例慢性ITP外周血IL:活性、T细胞亚群。结果ITP外周血IL_2活性降低,且与T_4/T_8比值呈正相关;ITP外周血T细胞亚群紊乱,表现外周血总T细胞、T辅助细胞百分率降低,T抑制细胞百分率增高。提示ITP存在细胞免疫功能异常。
IL_2 Level and T lymphocyte subsets in peripheral blood were studied by using ~3H-TdR in corporation assy and anti-T cell monoclonal antibody techniques in 21 patients with ITP and 18 health controls. It was showed that the IL_2 level in ITP patients was decreased significantly (P<0.001) as compared with that of the controls. T helper cell percentages and T total cell percentages in patients were less and T in hibiter cell percentages were much more that of the controls. There were positive correlation between the IL_2 level and the ratio of T_4/T_8 in 16 ITP patients. We suggest that the abnormalities of the T cell subsets and decreased IL_2 level in the peripheral blood of ITP patients might play a role of the pathogenesis of ITP
出处
《临床血液学杂志》
1993年第4期145-147,共3页
Journal of Clinical Hematology
