摘要
目的探讨Fas,FasL和TRAIL介导的细胞凋亡在尖锐湿疣发病中的可能作用及意义。方法用免疫组化方法检测了尖锐湿疣皮损中Fas,FasL,TRAIL的表达。结果所有尖锐湿疣标本中(100%)均有Fas阳性,23例(76.7%)FasL阳性,21例(70%)TRAIL阳性,三者分布基本一致,正常表皮基本不表达。且FasL和TRAIL分子与真皮单一核细胞浸润呈显著负相关(r=-0.506和r=-0.450,P<0.05)。结论尖锐湿疣组织中细胞凋亡相关分子Fas,FasL和TRAIL表达异常,且FasL,TRAIL分子表达影响局部免疫反应,考虑凋亡失控可能参与尖锐湿疣发病,引起复发。
Objective:To investigate the role of the expression of Fas,FasL and TRAIL in condyloma acuminata.Methods:Fas,FasL and TRAIL were determined by immunohistochemistry.Results:The expression of Fas was seen in all(100%)of specimen.23(76.7%)cases were FasL positive,and21(70%)cases were TRAIL positive.There was reduced infiltration of mononuclear cells(MNCS)in the dermis with intensive FasL and TRAIL staining and was a statistically significant inverse correlation(r=-0.506and r=-0.450respectively,P<0.05between them.Conclu-sion:Fas,FasL and TRAIL may involve in the regulation of apoptosis and may play an important role in the occur-rence and recurrence condyloma acuminata.
出处
《中国现代医学杂志》
CAS
CSCD
2004年第21期38-40,共3页
China Journal of Modern Medicine
