摘要
大蒜素在高浓度（５０ｕｇ／ｍｌ）时对Ｔ细胞激活有抑制作用。但在适当浓度（３．１２５～１２．５ｕｇ／ｍｌ）时则对Ｔ细胞激活有促进作用，这种促进作用与大蒜素抑制巨噬细胞产生ＮＯ的能力有关。大蒜素能够对抗Ｓ１８０细胞和艾氏腹水癌细胞产生的肿瘤免疫抑制因子对Ｔ细胞激活的抑制作用。提示大蒜素在肿瘤治疗中可能有较大的应用价值。
t high concentration (50ug / ml ). Allitridum had and inhibitory effect on T cell activation (compared with controlgroup. P<0. 05). But at appropriate concentrations (3. 125- 12. 5ug/ml). Allitridum augmented the activation of Tlymphocytes by Con A(compared with control group, P<O. 01). The augmentation of T cell activation by Allitridumwas related to the inhibitory effect of Allitridum on the production of nitric oxide(No)by macrophage. In addition, Allitridum could antagonize the inhibition of tumor-derived immunosuppressive factors produced by S180 cell and Ehrlichascitic cancer cell on the activation of T lymphocytes .and reduce the inhibitory rate significantly(P<O. 01),suggest-ing that Allitridum may be potentially useful in tumor therapy.
出处
《中药药理与临床》
CAS
CSCD
1995年第1期26-28,共3页
Pharmacology and Clinics of Chinese Materia Medica
