摘要
背景与目的:观察姜黄水提液对荷H22肝癌小鼠实体瘤的抑制作用及其对荷瘤鼠体内抗氧化能力的影响。材料与方法:建立移植性H22肝癌小鼠实体瘤的模型,灌胃给药,观察姜黄水提液及纯姜黄素给药后各处理组小鼠实体瘤重,肝重,脾重以及GSH、SOD的变化情况。结果:纯姜黄素组抑瘤率为37.97％,姜黄水提液各剂量组未见抑瘤作用。姜黄水提液与纯姜黄素均使荷瘤鼠体内GSH和SOD水平升高,两者效果相似。结论:中药姜黄水提液对H22肝癌小鼠实体瘤抑制作用不明显;但是姜黄水提液和纯姜黄素均能提高实验小鼠体内的CSH和SOD的水平,有良好的提高体内抗氧化能力作用。
BACKGROUND & AIM: To study the antioxidative and antitumor effcts of Curcuma longa L decoction on H22 tumorigenic mouse. MATERIAL AND METHODS: The H22 tumorigenic mice were oral administrated with the decoction with 24 g /kg, 12 g/kg and 6 g/kg curcuma longa L respectively for 8 days. Weight of tumor, both GSH and SOD activities of animal blood were determined. RESULTS: Inhibition of tumor growth was found for curcuma longa L decoction. But curcuma longa L decoction could significantly increase the levels of GSH and SOD on H22 tumorigenic mice blood. CONCLTJTION: In this investigation, Curcuma longa L decoction has no obvious antitumor effect, but has antioxidative effect on H22 tumorigenic mice.
出处
《癌变．畸变．突变》
CAS
CSCD
2004年第6期347-348,358,共3页
Carcinogenesis,Teratogenesis & Mutagenesis
关键词
姜黄
H22
抗肿瘤
抗氧化
Curcuma longa L
H22
antitumor
antioxiditant
