摘要
目的 研究盐酸阿比朵尔、盐酸金刚烷胺及利巴韦林在细胞Hep - 2培养中抑制呼吸道合胞病毒的作用。方法 采用细胞病变抑制法 ,测定 3种药物对呼吸道合胞病毒所致Hep - 2细胞病变效应的抑制作用。结果 3种药物抗呼吸道合胞病毒的IC50 依次为盐酸阿比朵尔 (38 2 μg·ml-1)、盐酸金刚烷胺 (6 8 0 μg·ml-1)和利巴韦林 (80 3μg·ml-1) ,TI分别为 5 2、2 7、4 7,其中盐酸阿比朵尔表现出较强的抑制呼吸道合胞病毒的效果。结论 在体外抗呼吸道合胞病毒的 3种实验药物中 ,盐酸阿比朵尔应为首选。
OBJECTIVE To observe the anti-respiratory syncytial virus effect of three kinds of medicine: Arbidol hydrochloride ,Amantadine and Ribavirin. METHODS The antiviral effect were observed by the technique of cell culture, The independent antiviral effect of the three kinds of medicines were compared. RESULTS The best inhibitor of respiratory syncytial virus was arbidol hydrochloride, with the IC 50 of 38.2 μg·ml -1 and TI is 5.2. CONCLUSION The study has provided the laboratory evidences that the best choice of medicine used to treat respiratory syncytial virus infection is arbidol hydrochloride.
出处
《华西药学杂志》
CAS
CSCD
2004年第6期427-429,共3页
West China Journal of Pharmaceutical Sciences
