摘要
目的 探讨母亲孕期糖尿病对子代脑发育的影响。 方法 通过颅脑超声测量 79例糖尿病母亲之新生儿额叶脑回宽度 ,与 10 8例同胎龄非糖尿病母亲的新生儿相比较 ,并分析母亲糖尿病控制情况与新生儿脑发育的关系及受母亲疾病影响的新生儿脑回宽度变化。 结果 糖尿病母亲之足月新生儿额上回宽度 (1.0 0 6± 0 .10 2 )cm及其起始段脑回宽度 (1.16 7± 0 .197)cm与非糖尿病母亲之新生儿 [额上回宽度 (0 .85 9± 0 .0 87)cm ,起始段脑回宽度 (0 .95 6± 0 .12 3)cm]比较 ,差异有显著性 (P <0 .0 1)。母亲孕期糖尿病未控制组新生儿额叶脑回宽度异常率 (47% )高于控制组 (37% ) ,但差异无显著性 (P >0 .0 5 )。受母亲糖尿病影响的新生儿脑发育过程中出现问题机会较高。 结论 母亲孕期患糖尿病有可能造成子代脑成熟障碍 ,可通过颅脑超声对新生儿脑回宽度测量予以评价。
Objective To study the effect of maternal diabetes during pregnancy on brain deve lopment of filial generation. Methods Cerebral gyri width of lobus frontals was measured in 79 infants of pregnant diabetic mother by ultrasound and the parameters were compared with 108 infants of non diabetic mother. We analyzed the relationship between the variation of cerebral gyri width and the diabetic control of the mothers. Brain development status in neonates with diabetic mothers was observed. Results Cerebral gyri width were significantly wider in the full term infants of diabetic mother (1.006±0.102)cm than that of the infants of non diabetic mother (0.859±0.087)cm. This was more obvious in the gyrus frontals superior and initial section[(1.167 ±0.197)cm vs (0.956 ± 0.123) cm]( P <0.01). The rate of infantile abnormal cerebral gyri width of un controlled maternal diabetes (47%) was higher than that of control groups (37%, P >0.05). Conclusions Maternal diabetes in pregnancy may result in filial generation brain immaturity. Cerebral ultrasound can be used to measure the cerebral gyri width.
出处
《中华围产医学杂志》
CAS
2004年第6期346-348,共3页
Chinese Journal of Perinatal Medicine
