摘要
目的 评价肾移植术后特异性HLA抗体对移植肾急性排斥的影响。方法 采用前瞻性队列研究 ,通过酶联免疫吸附 (ELISA)法检测 1 36例肾移植患者围手术期特异性HLA抗体水平 ,随访观察HLA抗体对急性排斥的影响。结果 术后HLA抗体阳性组急性排斥发生率高于阴性组(32 .6 5 %vs 1 3.79%,P =0 .0 0 0 )。按照HLA I类和Ⅱ类抗体水平分组后 ,移植肾无排斥存活率依次为 :HLA I - /Ⅱ -组 >HLA I- /Ⅱ +组 >HLA I +/Ⅱ -组 >HLA I +/Ⅱ +组 (P =0 .0 3)。结论术后特异性HLA抗体可能是引起移植肾急性排斥的原因之一 ,HLA I类抗体与急性排斥关系较为密切。
Objective To evaluate the clinical effect of anti-HLA antibodies on allograft acute rejection.Methods Perioperative sera of 136 cadaveric kidney recipients were tested by ELISA for anti-HLA I and Ⅱ antibodies in our prospective cohort study. All recipients who were divided into different groups according to HLA antibody production were followed up.Results Forty-nine recipients positive for anti-HLA antibody had an acute rejection rate of 32.65 %, compared with a 13.79 % rate in those negative for antibody (P= 0.000). The allograft acute rejection-free survival was observed as: HLA-I-/Ⅱ->HLA-I-/Ⅱ+>HLA-I+/Ⅱ->HLA-I+/Ⅱ+(Log-Rank test, P= 0.03).Conclusion Posttransplant HLA antibodies contributed to the episode of acute rejection. The production of anti-HLA class I antibodies was strongly associated with the occurrence of acute rejection.
出处
《中华器官移植杂志》
CAS
CSCD
北大核心
2004年第6期323-325,共3页
Chinese Journal of Organ Transplantation
