摘要
为探讨血清 HA、PCⅢ、Ⅳ-C、和 LN 水平对诊断肝纤维化的临床价值,对180例慢性肝病患者分别采用 RIA 测定血清HA、PCⅢ、Ⅳ-C 和 LN 水平。结果表明,血清 HA、PCⅢ、Ⅳ-C、和 LN 水平在慢性肝炎中度、重度及肝硬化患者明显高于对照组(P<0.05),且随着肝脏炎症和纤维化程度的加重而升高。结论是血清 HA、PCⅢ、Ⅳ-C 和 LN 水平可反映肝纤维化程度,四项联合检测是判断肝纤维化和早期肝硬化的无创伤性的、相对灵敏的指标。
To evaluate the diagnostic value of serum hyaluronic acid(HA),type Ⅲ procollagen(PC Ⅲ),typeⅣ collagen(Ⅳ- C)and laminin(LN)for hepatofibrosis,these 4 serum components were measured by RIAin180 cases with chronic ilver disease.The serum levels of HA ,PC Ⅲ,Ⅳ-C and LN in chronic hepatitis and cir-rhosis patients were significantly higher than those in the control group(P<0.05)and increased with the de-velopment of hepatitis and fibrosis.These items Could reflect the degree of hepatic fibrosis and might be the indicators of hepatic cirrhoses in early stage.
出处
《延安大学学报（医学科学版）》
2004年第4期35-36,共2页
Journal of Yan'an University:Medical Science Edition
