摘要
目的:了解尖锐湿疣(CA)患者系统和局部皮损细胞免疫功能的变化,以探讨细胞免疫功能对CA复发的影响。方法:通过流式细胞仪对21例初发CA患者、18例复发CA患者及23名正常人外周血进行T淋巴细胞亚群的检测,同时采用免疫组化染色方法对皮损进行CD4+/CD8+淋巴细胞染色,高倍显微镜下观察阳性细胞的数目。结果:初发CA和复发CA两组CD4+与CD8+细胞比值(1.04±0.50和1.01±0.59)均明显低于正常对照组(1.51±0.66,P<0.05),而两组间差异无显著性(P>0.05)。与正常对照组相比,两组CA局部皮损CD4+/CD8+比值(0.87±0.75和1.51±0.96)均明显降低(P<0.05),且复发CA组CD4+/CD8+比值也明显低于初发CA组,差异有显著性(P<0.05)。男女性患者不同部位皮损CD4+/CD8+比值均低于正常对照组,差异有显著性(P<0.05)。结论:CA患者存在全身和局部的细胞免疫功能低下,特别是局部细胞免疫功能低下在CA的复发中起着一定的作用。
Objective: To evaluate the role of systemic and local cell-mediated immunity in incidence and recurrence of condyloma acuminatum (CA). Methods: T lymphocyte subsets in peripheral blood were detected by flow cytometry while the expression of CD4+ T cell and CD8+ T cell in local lesions were determined by immunohistochemical technique. Results: The CD4+ / CD8+ ratio in peripheral blood in primary CA and recurrent CA (1.04±0.50 and 1.01±0.59 respectively) were significantly lower than that in normal controls (P < 0.05). There was a significant decrease in the ratio of CD4+/CD8+ in local lesions of the two CA groups (1.51±0.96 and 0.87±0.75 respectively) when compared to controls(P < 0.05). Also the CD4+ / CD8+ ratio in local lesions in recurrent CA was significantly lower than that in primary CA (P < 0.05). In addition, the ratios of CD4+/CD8+ in different locations of lesions were statistically lower than that in normal controls (P < 0.05). Conclusion: Patients with CA have low cell-mediated immunity, especially the low local cell-mediated immunity plays an important role in the recurrence of CA.
出处
《临床皮肤科杂志》
CAS
CSCD
北大核心
2005年第1期23-25,共3页
Journal of Clinical Dermatology
关键词
尖锐湿疣
T淋巴细胞亚群
condyloma acuminatum
T lymphocyte subsets
