4Kunou N, Ogura Y,Yasukawa T, et al. Long- term sustained release of ganciclovir from biodegradable scleral implant for the treatment of cytomegalovirus retinitis[J] .Control Release,2000,68(2) :263.
7Ando E,Yama Shita F,Tananka M,et al.A nevel chemotherapy for advanced hepatocellular Carcinoma with tumor thrombosis of the main trunk of portal veiv[J] .Cancer, 1997,79:1890.
3[1] Park H,Park K.Biocompatibility issues of implantable drug delivery systems[J].Pharm Res,1996,13(12):1770.
4[2] Anderson JM.In vivo biocompatibility of implantable delivery systems and biomaterials[J].Eur J Pharm Biopharm,1994,40(1):1.
5[3] Lewis DH.Controlled release of bioactive agents from lactide/glycolide polymers[A].In:Chasin M,Langer R,eds.Drug and Pharmaceutical Sciences.Vol 45:Biodegradable Polymers as Drug Delivery Systems[M].New York:Marcel Dekker,Inc.1990:1～41.
6[4] Holland SJ,Tighe BJ.Biodegradable polymers[A].In:Ganderton D and Jones T,eds.Advances in Pharmaceutical Sciences[M].London:Academic Press,1992:101～164.
8[6] Hausberger AG,Kenley RA,DeLuca PP.Gamma irradiation effects on molecular weight and in vitro degradation of poly (D,L-lactide-CO-glycolide) microparticles[J].Pharm Res,1995,12(6):851.
9[7] Heller J.Polymers for controlled parenteral delivery of peptides and proteins[J].Adv Drug Delivery Rev,1993,10(2-3):163.
4Bettini R, Acerbi D, Caponetti G, et al. Influence of layer position oil in vitro mid in vivo release of levodopa methyl ester and carbidopa fromthree-layermattlxtablets[ J ]. Eur J Pharm Biopharm, 2002,53 : 227 - 232.
5Kim CJ. Compressed donut-shaped tablets with zero order release kinetics[J]. Pharm Res, 2002,12:1045.
6Cheng K, Zhu J, Song X, et al. Studise on hydroxylpropyl methyleellu- fosedonut-shapedtablets [ J ]. Drug Dev Ind Pharm, 2001, 25:1067 - 1071.
7Morita R, Tionda R, Takahashi Y. Development of oral controlled rleasepreparations, a PVA swelling controlled release system (SCRC). I. Design of SCRS and its release controlling factor[J]. J Control Release, 2000,63 : 297.
8Mehm KA, IGslalioglu MS, Phuapmdit W, et al. Release performance of a poorlysoluble drag from a novel. Eudragit-based rouhi-unit erosion matrix[ J]. Int J Phann,2001,213 :7.
10Zheng W, McGinity JW. Influence of Eudragit HE 30D blended with Eudragi30D -55 on the rel of phebylpropanolamine hydrochloride from coated pellets [ J ]. Drug Dev Ind Pharm,2003,29:357 -366.
