摘要
目的 :研究扶正防喘颗粒剂的成型工艺。方法 :根据扶正防喘颗粒剂所含药材丹参、补骨脂等中的主要活性成分的特性 ,以颗粒剂的成型性、溶化时间及口感为考察指标 ,试验优选颗粒剂的辅料。结果 :优选辅料为β- CD,乳糖 ,甘露醇 ,CMS- Na,阿斯巴甜 ,PVP。颗粒剂成型制备工艺采用 16目筛 ,湿法制粒 ,6 0℃以下真空干燥的制备工艺。结论 :颗粒剂所选辅料合理 。
Objective:To study Fuzheng Fangchuan Granules moulding process.Methods:Fuzheng Fangchuan Granules is a new traditional Ch inese Medicine. It is made from Radix Salviae.Fructas Psoralea.To finish the exp eriments,many appropriate methods were adopted in term of the main effective com pound. The better formulation design of granules,mobile capability、time of reso lution and tasty were selected as variable factors.Results:The appropriate excipients that were selected were β-CD、 lactose、mannitol、aspartame、PVP etc. the granules preparation process used 16# net by wetting agent and drying temperature is below 60℃.Conclusion:The formula of granules was completed and reaso nable.The moulding technology of granules was convenient and credible, totally m atched to the requests of the granules.
出处
《时珍国医国药》
CAS
CSCD
2004年第12期831-832,共2页
Lishizhen Medicine and Materia Medica Research
关键词
扶正防喘颗粒
成型工艺
Fuzheng Fangchuan Granules
Moulding p rocess
