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创伤性休克肠系膜淋巴液影响中性粒细胞CD18和CD11b表达及肺损伤的实验研究 被引量:1

Experimental research of neutrophil adhesion expression(CD18 and CD11b)in intestinal lymph of trauma-induced shock and lung injury
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摘要 目的 探讨创伤性休克的小肠淋巴液对中性粒细胞CD18和CD11b表达及肺损伤的干预情况。方法 健康大鼠 32只 ,随机分成 4组 :休克淋巴管结扎组、休克淋巴管未结扎组、假休克淋巴管结扎组、假休克淋巴管未结扎组 ,分别观察各组大鼠予休克或假休克后 1小时 ,3小时CD18,CD11b的表达及肺损伤情况。结果  (1)休克淋巴管结扎组、休克淋巴管未结扎组分别与假休克淋巴管结扎组、假休克淋巴管未结扎组比较 ,1小时、3小时中性粒细胞CD18和CD11b的表达及肺损伤都明显增加 (P <0 0 5 ) ;(2 )假休克淋巴管结扎组、假休克淋巴管未结扎组比较 ,1小时、3小时中性粒细胞CD18和CD11b的表达及肺损伤的情况没有明显差异 (P >0 0 5 ) ;(3)休克淋巴管结扎组与休克淋巴管未结扎组比较 ,1小时、3小时中性粒细胞CD18和CD11b的表达及肺损伤情况都明显降低 (P <0 0 5 )。结论 预先结扎小肠系膜淋巴管可以明显降低创伤性休克大鼠中性粒细胞CD18和CD11b表达及缓解肺损伤 (P <0 0 5 )。
出处 《浙江实用医学》 2004年第5期305-307,共3页 Zhejiang Practical Medicine
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