摘要
以伊曲康唑及其盐酸盐为模型药物,以相溶解度为考察指标,探讨了影响羟丙基-β-环糊精增溶作用的因素,如平均取代度、摩尔浓度、药物溶解性能、离子强度、pH和温度等。结果表明,伊曲康唑的相溶解度与环糊精中羟丙基的平均取代度成反比,与环糊精摩尔浓度成正比。
Using itraconazoleanditshydrochlorideasmodel drugs and thephasesolubility asevaluationparameter, theinfluence factorssuch asdegree of substitution, mol concentration,the solubility of drug,ion strength,pH and tempera- ture on solubilization of hydroxypropyl-β-cyclodextrin were examined. The results showed that the phase solubility of itraconazole wasin the inverse ratio with the degree of substitution, and in the direct ratio with the mol concentration.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2004年第12期727-729,共3页
Chinese Journal of Pharmaceuticals
