摘要
目的 :评价远端保护装置在急性心肌梗死 (acutemyocardialinfarction ,AMI)急诊介入治疗 (percutaneouscoronaryintervention ,PCI)中的应用价值 .方法 :临床选择2 0 0 3 0 6 / 2 0 0 4 0 3收住西京医院心血管内科发病 2h至 3d内急诊入院的AMI患者 72例 ,根据意愿分为对照组、实验组(介入治疗时使用远端保护装置 ) .实验组纳入 39(男 36 ,女3)例 ,平均年龄 (5 6± 12 )岁 ;对照组纳入 33(男 2 7,女 6 )例 ,平均年龄 (5 9± 12 )岁 .肘静脉采血查血清肌钙蛋白I(cTnI) ,心肌酶CK MB (CK MB)含量 ,时间点分别为入院时、PCI术后8,16和 2 4h .结果 :①血清cTnI和CK MB含量变化 :实验组峰值均在术后 8h出现 ,且在 16 ,2 4h显著降低 ,与对照组比较有明显差别 [cTnI 16 ,2 4h分别为 (12 0 1± 814 )vs (6 93± 6 2 4 ) μg/L ,P <0 .0 1;(110 0± 186 8)vs (417± 36 5 ) μg/L ,P <0 .0 1.CK MB 16 ,2 4h分别为 (4.92± 1.32 )vs (3.2 7±0 .33) μkat/L ,P <0 .0 1;(3.0 2± 0 .13)vs (2 .5 7± 0 .13)μkat/L ,P <0 .0 1].②两组住院期间心血管病事件发生率无明显统计学差别 .结论 :AMI急诊介入治疗时血栓和粥样斑块脱落破裂造成远端血管栓塞 ,出现冠状动脉无复流现象 ,远端保护装置回收脱落碎片 ,有效预防?
AIM: To evaluate the safety and efficiency of distal protection device during primary angioplasty in acute myocardial infarction. METHODS: Seventy-two hospitalized acute myocardial infarction (AMI) patients in the Department of Cardiology of Xijing Hospital from June 2003-Mar 2004 were included in this study. The patients were divided into two groups of their own will: experimental group (n=39) with 36 males and l3 females, and control group (n=33) with 27 males and 6 females. Blood samples were collected from the elbow vein at 8, 16 and 24 h after percutaneous coronary intervention (PCI) and the serum level of cTnI and CK-MB were measured. The difference of the incidence rate of cardiovascular events during the hospitalization between the two groups was compared. RESULTS: ①The serum level of cTnI increased after PCI in both of the two groups, but that of experimental group reached peak at 8 h after PCI,while that of control group reached peak at 16 h after PCI. The serum levels of cTnI and CK-MB were also significantly lower in experimental group than those in control group at 16 h and 24 h after PCI [cTnI 16 h (1201±814) vs (693±624) μg/L, P<0.01;24 h (1100±1868) vs (417±365) μg/L, P< 0.01 . CK-MB 16 h (4.92±1.32) vs (3.27±0.33) μkat/L, P<0.01;24 h (3.02±0.13) vs (2.57± 0.13) μkat/L, P<0.01]. ② The incidence rate of major adverse cardiac events(MACE) was not significantly different between the two groups during hospitalization. CONCLUSION: It is feasible, safe and effective to use the distal protection device in native coronary against embolism during primary angioplasty in AMI.
出处
《第四军医大学学报》
北大核心
2004年第23期2148-2151,共4页
Journal of the Fourth Military Medical University
基金
西京医院科技创新基金 (XJCX0 3M 0 1 9)
关键词
急性心肌梗死
远端保护装置
介入治疗
肌钙蛋白I
心肌酶CK.MB
acute myocardial infarction
distal protection device
percutaneous coronary intervention
cardiac troponin I
creatine kinase MB
