摘要
目的 探讨慢性肾小球疾病尿细胞因子改变及其与中医证型的关系。方法 对1 1 0例慢性肾小球疾病患者尿中白细胞介素 - 6 (IL - 6 )、转化生长因子 - β1 (TGF - β1 )及内皮素 - 1 (ET - 1 )进行了测定。结果 肾病综合征、慢性肾炎及慢性肾功能衰竭患者尿中IL - 6、TGF - β1 及ET - 1与健康对照组相比均有显著性差异 (P <0 .0 1或 0 .0 5 ) ,各型之间亦有一定的差异 (P <0 .0 1或 0 .0 5 )。中医证型阳虚型尿中TGF - β1 及ET - 1显著增高 (P均 <0 .0 1 ) ,气虚型及阴虚型均有尿IL - 6显著增高 (P <0 .0 1 ) ,但气虚型尿TGF - β1 亦增高 (P <0 .0 5 ) ;水湿证及湿热证尿IL - 6、TGF - β1 及ET - 1均显著增高 (P <0 .0 1或 0 .0 5 ) ,但TGF - β1 低于阳虚型 (P <0 .0 5 )。结论 不同临床类型及不同中医证型的肾小球疾病尿细胞因子的水平各有一定的特点 ,因此 ,尿细胞因子检查对中医辨证分型及了解肾内病理改变有一定的参考价值 ,从而为临床治疗提供相应的针对性。
Objective It is to discuss the urine cytokine change and the relationship between it and traditional Chinese medical syndrome type in chronic renal glomerular disease.Methods Urine interleukin-6 (IL-6), transfer growth factor-β_1 (TGF-β_1) and endothetin-1 (ET-1) were mensurated in 110 patients with primary chronic renal glomerular disease.Results Urine IL-6, TGF-β_1 and ET-1 in patients of nephrotic syndrome, chronic nephritis and chronic renal failure had significant differences compared with those in healthy control group (P<0.01 or 0.05). There were also significant differences among those types (P<0.01 or 0.05). Urine TGF-β_1 and ET-1 in Yang-asthenia patients were significant higher than those in other patients (P<0.01). Urine IL-6 in both Qi-asthenia and Yin-asthenia patients heightened significantly (P<0.01), but urine TGF-β_1 in Yin-asthenia patients also heightened (P<0.05). Urine IL-6, TGF-β_1 and ET-1 in water-wetness and wetness-heat patients heightened significantly (P<0.01 or 0.05), but urine TGF-β-1 in those patients were lower than that in Yang-asthenia patients (P<0.05).Conclusion Urine cytokine level has respectively definite characteristic in renal glomerular disease patients with different clinical types and different TCM syndrome types. So urine cytokine tested has definite reference value on TCM discriminate syndrome type and understanding pathological changes in kidney, which can offer corresponding pertinence to clinical treatment accordingly.
出处
《现代中西医结合杂志》
CAS
2005年第1期20-22,共3页
Modern Journal of Integrated Traditional Chinese and Western Medicine
关键词
慢性肾小球疾病
白细胞介素-6
转化生长因子-Β
内皮素-1
中医证型
chronic renal glomerular disease
interleukin-6
transfer growth factor-β_1
endothetin-1
traditional Chinese medical syndrome type
