摘要
目的:对孕妇进行锌干预后,观察其妊娠结局及其新生儿生长发育情况,以探讨锌干预与妊娠结局和新生儿发育的关系。方法:2002-04/2003-04在广西医科大学第一附属医院妇产科门诊建立优生保健卡,并定期产前检查,住院分娩的孕妇1031例。符合标准的孕妇670名。干预对象自建立优生保健卡之次日起口服葡萄糖酸锌口服液30mL。遵循1∶1配对的原则从同期孕检妇女中选取相应1名对照,对照组不进行锌元素制剂增补。所有研究对象分别在第1次孕期保健、孕27～29周及产前抽取静脉血,测定全血锌浓度。并记录孕妇的年龄、身高、孕前体质量、职业、家庭月人均收入、文化程度、孕产史、孕期情况、妊娠结局以及新生儿情况等内容。结果:对照组孕妇不同孕期全血锌浓度犤孕早期(6.29±1.88)mg/L,孕中期(5.59±1.41)mg/L,孕晚期(5.19±1.20)mg/L犦比较,差异有显著性意义(F=528.786,P<0.01),随着孕期的进展而逐渐下降。干预组孕妇不同孕期全血锌浓度差异无显著性意义(P>0.05)。干预组的胎儿宫内发育迟缓、低体质量儿的发生率低于对照组(χ2=24.4123,40.4794,P<0.01);干预组的先天畸形发生率低于对照组(χ2=4.6558,P<0.05)。干预组新生儿出生体质量、头围显著大于对照组,干预组身长、1minApgar评分显著高于对照组(t=14.581,4.841,4.
AIM:To observe the pregnancy outcomes and fetal development after zinc intervention in pregnant women so as to explore the correlations of zinc intervention with pregnancy outcomes and infant development.<METHODS:During April 2002 and April 2003,health care card for eugenic engineering was established for the 1031 women who were hospitalized to give birth in the clinic of Department of Obstetrics & Gynecology,the First Affiliated Hospital of Guangxi Medical University.They received antepartum examination regularly,and 670 were in accordance with inclusion criteria of the health care card.Totally 335 pregnant women were selected as subjects of intervention group,and rest of the 670 pregnant women were as subjects of control group with 1∶ 1 matching principle.Only subjects in the intervention group were given zinc gluconate supplement(oral solution) 30 mL per day orally since the day the health care card was established.Meanwhile,the venous blood samplings of all subjects in the two groups were drawn at the first maternal examination,27- 29 pregnant weeks and just before baby delivery respectively,to test the zinc concentration in whole blood samplings.The age,height,progestational body mass,occupation,monthly per capita income of a family,education level,pregnant history,pregnant state of the subjects pregnancy outcomes and infant development were collected with questionnaire.<RESULTS:The zinc concentration of whole blood in the control group was significantly different at different gestation periods[(6.29± 1.88) mg/L,(5.59± 1.41) mg/L and (5.19± 1.20) mg/L during early,middle and late gestation respectively](F=528.786,P< 0.01),so accordingly,it decreased gradually during gestation,but it was found insignificantly different in the intervention group during gestation(P >0.05).The incidence of intrauterine developmental retardation(χ 2=24.412 3,P< 0.01),lower body mass(χ 2=40.479 4,P< 0.01) and malformations(χ 2=4.655 8,P< 0.05) in the intervention group was significantly lower than that in the control group.Birth body mass was heavier,head circumference and birth length longer,1 minute Apgar score higher in offspring from the intervention group than from the control group(t=14.581,4.841,4.895,15.001,P< 0.01).<CONCLUSION:Daily proper zinc supplement in pregnant women can obviously promote zinc nutrition during middle and late gestation,ameliorate pregnancy outcomes and parameters of infant development.
出处
《中国临床康复》
CSCD
2004年第36期8298-8299,共2页
Chinese Journal of Clinical Rehabilitation
基金
广西壮族自治区科技厅自然科学基金资助项目(桂科自0144008)~~
