摘要
目的探讨阿托伐他汀对不稳定性心绞痛(UA)患者血小板活性因子CD41、CD63、CD62P表达、血浆高敏C反应蛋白(hsCRP)和颈动脉粥样硬化的影响及机制。方法测定30例UA患者在常规治疗基础上加服阿托伐他汀20mg,治疗6个月及12个月前后血小板CD41、CD63、CD62P、血浆hsCRP浓度及经彩色多普勒技术测定的颈动脉内膜厚度、血流参数及颈动脉斑块的变化,并与常规治疗30例作为对照组。结果30例UA患者经阿托伐他汀治疗6个月后血小板CD41、CD63、CD62P及血浆hsCRP测定值分别显著低于治疗前水平(P<005或P<001);并降低双侧颈动脉内膜厚度,斑块面积缩小,改善颈动脉血流参数,12个月后上述各项参数改变更为明显,与常规治疗对照组及治疗前比较,差异有显著性(P<001)。结论阿托伐他汀通过抗血小板活化、抗炎等机制对防治不稳定性心绞痛早期动脉粥样硬化及稳定斑块起着重要的作用。
Objective To observe the influence of atorvastatin on platelet CD41、CD63、CD62P and serum high sensitive C Reactive Protein (hs CRP)levels and arteriosclerosis plaque of carotid artery in patients with unstable angina. Methods Thirty subjects with arteriosclerosis plaque of carotid artery were given atorvastatin 20 mg qd for 12 months. The serum levels of CD41、CD63、CD62P and hs CRP were detected before and 6 months after treatment. The intima media thickness (IMT) and arteriosclerosis plaque of carotid artery were measured before and 6 and 12 months after treatment in all patients with Doppler ultrasonograph. Results After 6 and 12 months adminstration of atorvastatin, the levels of CD41、CD63、CD62P and hs CRP were all reduced ( P <0 01). The initial diameter of carotid was significantly enlarged ( P <0 01).The size of plaque and IMT reduced significantly in 12 month after atorvastatin therapy ( P <0 01). All the parameters of blood flow in carotid artery were improved significantly ( P <0 01). Conclusion Atorvastatin decreased inflammatory reaction and antiplatelet activation in patients with unstable angina, which may improve stabilization of the plaque in carotid artery.
出处
《中华心血管病杂志》
CAS
CSCD
北大核心
2004年第11期977-980,共4页
Chinese Journal of Cardiology
