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超广谱和耐酶抑制剂β-内酰胺酶的研究进展 被引量:11

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摘要 产超广谱和耐酶抑制剂 β -内酰胺酶是革兰阴性菌对 β -内酰胺类抗生素耐药的重要原因。近几十年 ,这些酶的种类迅速增加 ,掌握它们的分类、构效关系和耐药模式等方面的知识 ,对临床合理使用抗生素和防止耐药菌的产生具有重要意义。对超广谱和耐酶抑制剂 β -内酰胺酶的最新分类 ,它们水解 β -内酰胺类抗生素的主要结构特点 ,及其氨基酸位点突变对构效关系的影响进行了介绍。
出处 《国外医药(抗生素分册)》 CAS 2005年第1期9-14,共6页 World Notes on Antibiotics
基金 国家高科技发展 863计划项目 (2 0 0 1AA 2 1 50 51 )
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