摘要
目的:对注射用苦参碱的药物组成进行分析并研究其临床应用的效果。方法:采用反相高效液相色谱法,以215nm 为检测波长,进行含量检测及卡尔费休氏法进行水分测定。将生产的注射用苦参碱应用于临床,并进行调研总结。结果:注射用苦参碱在 pH 值6.0～8.0时易于吸收,将其应用于临床后,经6个月随访发现,其综合疗效评价,有效率为47%。结论:注射用苦参碱能有效抑制肝细胞异常凋亡,同时阻断和减轻肝纤维化程度,与公认的治疗肝炎有效药物的疗效基本相似,且所采用的冻干粉针剂型,可避免药品因高热而降解,易于长期保存,可保持药品的稳定性。
Objective:The groups of Matrine for injection are analysed and its used effect is studied.Methods:Adopting the opposite phase high efficiency liquid phase chromatography and wavelength with 215nm,physical content is tested and water content examine is tested by method of Ka Erfei Xiu Matrine for injection which is producted is used to clinic and summed up to study. Result:Matrine for Injection is easy to be absorbed from pH 6.0 to pH 8.0.After being used in clinic,its synthetical curative effect are 47% during 6 months fellowed visits.Conclusion:Matrine for Injection can effectively repress the liver cell particular withers,obstruct and ease the liver fi- bral degree.It has the same effect which is publicedly believed as the most effect to hepatitis.And adopted drying and freezing mould,it can avoid to be soluted as a result of high heat and be easy to conserved in along period of time and keep chemical reagents stability.
出处
《黑龙江医药》
CAS
2004年第6期422-424,共3页
Heilongjiang Medicine journal
