摘要
以茄呢淳为原料,以4种药物为酰化基团,合成了N茄呢基酰胺(5a^5d)和N酰基N′茄呢基哌嗪(6a^6d)8种新的茄呢醇衍生物,其结构经元素分析、IR、1HNMR、MS测试技术确证。8个化合物对Bel7402(人肝癌细胞)均有弱的抑制作用,对HCT8(人结肠癌细胞)均有负的抑制作用,对KB(人口腔上皮癌细胞)的体外抑制活性也较低,甚至部分负抑制作用。
Eight solanesyl derivatives including N solanesylamides(5a^5d) and N acyl N ′ solanesylpiperazines(6a^6d) were synthesized with solanesol as starting material and four commercial drugs as the sources of acyl groups. All the products were characterized by 1 H NMR, IR, MS and elemental analyses. The inhibition activities of 5a^5d and 6a^6d to KB, Bel 7402, HCT 8 cells were biologically evaluated in vitro , the results show these compounds only have poor anti tumor activity.
出处
《应用化学》
CAS
CSCD
北大核心
2005年第1期50-54,共5页
Chinese Journal of Applied Chemistry
基金
.河南省科技厅(0323024000
0311020900
0423031800)
河南大学重点学科资助项目
