摘要
目的 :观察低 5 羟色胺 (5 HT)状态下脑血管对一氧化氮 (NO)的敏感性增高现象 ,及大川芎丸的干预作用。方法 :运用微循环技术观察软脑膜血管管径。腹腔注射对氯苯丙胺酸 (PCPA)造成低 5 HT状态 ,以观察脑血管对NO的超敏现象 ;连续灌胃大川芎丸 7d后 ,以观察该药对正常状态和低 5 HT状态扩张血管的干预作用。结果 :低 5 HT状态下 ,NO扩张脑血管的作用明显强于正常状态。大川芎丸可以抑制低 5 HT状态下NO导致的脑血管的过度扩张。结论 :低 5 HT状态下 ,脑血管对NO的反应性增强 ;大川芎丸可以抑制脑血管的过度扩张 ,可能是其治疗偏头痛的作用机制之一。
Objective:To observe the enhanced sensitivity of the cerebral vascular NO under hyposerotonin and the pharmacological effect of Dachuanxiong Pill.Method:the diameter of paiamatral vascular was observed using microcircular technique;The hyperserotonin was establishal by intraperitoneal injection of PCPA in rats;Intervention of Dachuanxiong Pill in vascular oliation induced by NO under normal and hyposerotonin state was inverstigaterol after intragastric administration of Dachuanxion Pill for seven days.Result:The vascular dilation induced by NO under hyposerotonin is more obvious than in normal state.Dachuanxiong Pill showed antagonism to excessive vasodilatation induced by No under hyposerotonin.Conclusion:Hyposerotonin has significan enhance of cerebral vascular to No;Dachuanxiong Pill an inhibition of the cerebral vascular dilation,which may one of for trentment of migraine indicated.
出处
《中国实验方剂学杂志》
CAS
2005年第1期28-30,共3页
Chinese Journal of Experimental Traditional Medical Formulae
