摘要
目的 探讨持续静滴和一次性静脉注射呋塞米治疗原发性肾病综合征患儿水肿的药效学。方法 采取自身对照方法 ,对 2 0 0 1年 5月至 2 0 0 2年 1月在中山大学附属第一医院就诊的 2 4例原发性肾病综合征患儿应用两种给药方式 ,观察药效学。结果 在持续静滴的 6h中 ,患儿的尿量、尿钠和尿钾的排出比静脉一次注射多 ,尤以尿量为著 (P <0 0 5 ) ;持续静滴和静脉推注患儿尿量在治疗中的 6h与后 6h相比 ,各自差异有显著性 (P均 <0 0 5 )。1例患儿在推注呋塞米时出现恶心 ,可自行缓解 ,未见其它副作用。结论 治疗肾病综合征患儿水肿 ,持续静滴呋塞米较一次性静脉注射呋塞米更有效、更安全。
Objective To assess the pharmacodynamic effects of continuous versus intermittent furosemide infusion in pediatric patients of nephrotic syndrome with edema.Methods We undertook a auto control trial in 24 pediatric patients of nephrotic syndrome with edema.Results The urinary output,the amounts of urinary Na,K excretion for the first 6 hours in the 2 nd day were greater than those in the 1 st day,especially the urinary output (P<0 05).Comparison of the first 6 hours versus the second 6 hours during the treatment,whether through continuous or intermittent furosemide infusion,the urinary output decreased markedly (P<0 05).Only one patient who received the intermittent furosemide infusion presented slight vomiting.Conclusion Continuous furosemide infusion is more effective and safe than intermittent furosemide infusion in pediatric patients of nephrotic syndrome with edema.
出处
《中国实用儿科杂志》
CSCD
北大核心
2005年第1期33-34,共2页
Chinese Journal of Practical Pediatrics
