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数字微阵列点样喷头试验研究 被引量:5

Experimental Research on Digital Spotting Head for Microarrays
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摘要 利用压电陶瓷驱动器产生的低频微振动,实现了连续微流体的均匀离散和喷射。在试验所用的低频范围内(1~10Hz),点样系统能够对每个驱动脉冲作出响应,具有数字可控性。通过疏水化处理技术消除微喷嘴的“流挂”现象,实现了微喷射量可控。微振动可以有效地消除微小颗粒可能对微喷嘴造成的堵塞,提高了点样喷头工作的可靠性。驱动频率对液滴直径有显著的影响。可以通过改变频率高低和微喷嘴内径大小实现皮升(pL)级点样喷射。 Uniform discretization and injection of microfluid have been realized by means of low frequency vibration of the piezoelectric ceramic actuators. The spotting system responds to each driving impulse (1Hz ~ 10Hz) and can be controlled digitally. As surface hydrophobization to the micro-nozzle has eliminated the spontaneous flowing of the microfluid in the micro-nozzle due to surface wetting effect, the volumes of each injection droplet are controllable and uniform. It has been proved that micro-vibration is an aid to eliminate micro-nozzle blockage from micro-particles and enhances reliability of the digital spotting head. Working frequency of piezoelectric ceramic actuators has a remarkable effects on the size of droplets. Micro-injection of a few of pico liters has been realized through changing working frequency and size of the micro-nozzle.
机构地区 南京理工大学
出处 《中国机械工程》 EI CAS CSCD 北大核心 2005年第1期46-50,共5页 China Mechanical Engineering
基金 国家自然科学基金资助项目(50275079) 高等学校博士学科点专项科研基金资助项目(2001028813)
关键词 点样 微阵列 微喷嘴 离散化 微喷射 spotting micro-array micro-nozzle discretization micro-injection
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