摘要
目的探讨乳头状甲状腺癌基质金属蛋白酶9(MMP9)表达的临床意义。方法采用SP免疫组化方法检测62例乳头状甲状腺癌及28例相应癌转移淋巴结MMP9的表达,分析其与临床病理特性的关系。结果乳头状甲状腺癌MMP9阳性表达率为79.0%(49/62),并且随着浸润程度的加深和淋巴结转移的出现而逐渐增强(均P<0.05);癌转移淋巴结MMP9阳性表达率为100.0%(28/28),与相应原发癌灶同步表达。结论MMP9过度表达与乳头状甲状腺癌的浸润和淋巴结转移密切相关。
Objective To investigate the significance of matrix metalloproteinase-9 expression in human papillary thyroid carcinomas(PTC). Methods The expression of MMP-9 was detected immunohistochemically in 62 PTC and 28 lymph nodes with corresponding cancer metastasis. The association was analysed between the positive rate of MMP-9 and the clinicopathologic features of PTC.Results The positive rate of MMP-9 expression was ~79.0% (49/62)and ~100.0% (28/28)in primary PTC and metastatic lymph nodes respectively. The expression of MMP-9 was enhanced with the increase of the depth of invasion and lymph node metastasis.Conclusion The overexpression of MMP-9 was significantly correlated with invasion and lymph node metastasis of PTC.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
2005年第1期11-12,共2页
Cancer Research on Prevention and Treatment
