摘要
【目的】探讨乌司他丁对肺癌化疗后病人单肺通气时炎性因子的影响。【方法】择期行肺癌手术病人30例,按美国麻醉医师协会(ASA)分级,Ⅰ～Ⅲ级;随机分为对照组(C组)和乌司他丁组(U组),每组各15例。U组给予乌司他丁1万U·kg-1,于麻醉诱导后缓慢静注,C组用等量生理盐水代替。分别于麻醉诱导后(S1),单肺通气40min(S2),单肺通气90min(S3),术毕双肺通气30min(S4)时,术后24h(S5)分别采取外周静脉血样测IL-8和IL-10质量浓度。【结果】两组IL-8于S3、S4、S5时均显著升高(P <0.05),和C组比较,U组S3、S 4时均显著降低(P <0.05),两组IL-10于S3、S4、S5时均显著升高(P <0.05),和C组比较,U组S3、S4时均显著升高(P <0.05)。【结论】乌司他丁可减轻化疗后病人单肺通气期间炎性细胞因子IL-8的生成和释放,增强抗炎性细胞因子IL-10的生成和释放,从而减轻病人的炎症反应。
To investigate the effects of ulinastatin on inflammatory factors in patients after chemotherapy during one lung ventilation.Thirty patients with lung cancer after chemotherapy for selective pulmonary surgery(ASA Ⅱ-Ⅲ) were selected and were randomly divided into two groups: control group (group C, n = 15) and ulinastatin group (group U, n=15). Group U: Patients received ulinastatin 10 000 U·kg-1 iv after induction of anesthesia. Group C: Patients received equal volume of normal saline instead of ulinastatin. Blood concentrations of IL-8 and IL-10 from peripheral vein were determined after induction of anesthesia (S1), 40 min after one-lung ventilation in the lateral position (S2), 90 min after one-lung ventilation in the lateral position (S3), 30 min after two-lung ventilation at the end of the operation (S4); 24 h after operation (S5). Plasma IL-8 concentrations increased significantly at S 3-5 in both group as compared with the baseline values and were significantly lower at S 3-4 in ulinastatin group than in group C (P < 0.05). Plasma IL-10 mass concentrations increased significantly at S 3-5 in both groups and were significantly hegher at S3-4 in ulinastatin group than in group C (P < 0.05). [Conclusion] Ulinastatin can effectively decrease the level of plasma IL-8 and upgrade the level of plasma IL-10 in the patients after chemotherapy.
出处
《中山大学学报（医学科学版）》
CAS
CSCD
北大核心
2005年第1期95-98,共4页
Journal of Sun Yat-Sen University:Medical Sciences
