摘要
目的 观察葛根素注射液联用黄芪注射液对 2型糖尿病肾病微量蛋白尿的治疗作用。方法 将确诊为2型糖尿病肾病的 78例患者随机分为治疗组 41例 ,给予葛根素注射液 5 0 0mg·d 1,加用黄芪注射液 3 0mL·d 1;对照组3 7例 ,单用黄芪注射液 3 0mL·d 1,两组均静脉滴注 ,均以 2周为 1个疗程。观察两组治疗前后的总胆固醇 (TC)、三酰甘油 (TG)、低密度脂蛋白 (LDL C)、高密度脂蛋白 (HDL C)、血细胞比容 (PCV )、血小板聚集率 (PAGT )、凝血因子Ⅰ (FIB)及 2 4h尿微量蛋白 (UAER)等指标的变化。结果 治疗组治疗后上述各项指标与治疗前均显著改善 (P <0 0 5或P <0 0 1) ;治疗后除TC、LDL C外 ,其他指标的改善均比对照组显著 ,差异有显著性或极显著性 (P <0 0 5 ,P <0 0 1)。结论 葛根素注射液有较好的调节血脂、改善血粘度及降低尿蛋白排泄率的作用。葛根素注射液加用黄芪注射液治疗 2型糖尿病肾病的疗效比单用黄芪注射液好 ,两者有协同作用。
Objective To observe the therapeutic effects of puerarin injection combined with radix astragli injection on urine micro-protein in patients with type 2 diabetic nephropathy. Methods Seventy-eight patients with type 2 diabetic nephropathy randomised into the treatment group (41 cases) and the control group (37 cases).The control group were treated with radix astragli injection 30 mL·d -1, iv, gtt, qd, and the treatment group received the same medicine combined with puerarin injection 500 mg·d -1 iv, gtt, qd.Both groups were treated for 2 weeks.The parameters of blood plasma such as TC, TG, PAGT, FIB and UAER were tested before and after the treatment. Results In the treatment group, the average values of the tested parameters were decreased significantly after the treatment than before the treatment (P<0.05 or P<0.01).Except TC and LDL-C, the average values of the tested parameters were also lowered significantly in the treatment group than in the control group (P <0.05 or P <0.01). Conclusion Puerarin injection can lower the blood lipids, improve blood viscosity, and decrease urine protein.The combination of puerarin injection with radix astragli injection has better effect than radix astragli injection alone in the treatment of type 2 diabetic nephropathy.
出处
《医药导报》
CAS
2005年第1期38-40,共3页
Herald of Medicine
关键词
黄芪注射液
葛根素注射液
糖尿病肾病
2型
尿微量蛋白
Radix astragli injection
Puerarin injection
Diabetic nephropathy,type 2
Urine micro-protein
