摘要
目的 探索帕金森病 (Parkinson sdisease ,PD)病人丘脑和纹状体质子磁共振波谱变化 ,评价质子磁共振波谱技术用于帕金森病的诊断和病理生理研究的价值。方法 采用质子磁共振波谱技术检测 2 2例帕金森病人与 12例年龄匹配的健康对照者双侧丘脑、纹状体NAA、Cho、Cr含量 ,分析比较NAA/Cr、Cho/Cr、NAA/Cho比值的变化。结果 PD患者丘脑NAA/Cr比值较正常组明显降低 (P <0 0 5 ) ,NAA/Cho、Cho/Cr无明显变化 ;患者纹状体NAA/Cho、NAA/Cr、Cho/Cr与正常对照组没有明显区别。结论 NAA/Cr降低是评价PD患者神经元功能损害的重要指标 ,质子磁共振波谱技术可以作为进一步研究帕金森病病理生理过程和诊断的无创性检测方法。
Objective To investigate the changes of proton magnetic resonance spectroscopy(MRS) in the thalamus and corpus striatum in patients with Parkinsons disease(PD). And to evaluate the effects of the technique in the pathophysiologic process and the diagnose of PD. Methods The content of NAA, Cho and Cr in thalamus and corpus striatum in twenty two patients and twelve age matched healthy controls were examined with proton MRS. The ratios of NAA/Cr, Cho/Cr and NAA/Cho were calculatd. Results The ratio of NAA/Cr in the thalamus in PD patients showed significant reduction compared to the controls. However, no significant differences were found in other ratios of these two areas. Conclusions The reduction of NAA/Cr ratio in thalamus in PD patients may indicate the dysfunction of the neurons. Proton MRS may be used as a noninvasive way to diagnose PD and to understand the pathophysiologic process of the disease.
出处
《中国神经精神疾病杂志》
CAS
CSCD
北大核心
2005年第1期47-49,共3页
Chinese Journal of Nervous and Mental Diseases
关键词
帕金森病
质子磁共振波谱分析
丘脑
纹状体
Parkinson's disease Proton magnetic resonance spectroscopy Thalamus Corpus striatum
