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人胚胎干细胞建系及体外诱导分化的研究进展 被引量：3

Advances in establishment of human embryonic stem cell and in vitro induced differentiation
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摘要 人胚胎干细胞源自囊胚内细胞团 (innercellmass,ICM ) ,能无限增殖并保持未分化状态 (保持完整的、正常的染色体核型 )的细胞。它可分化为来源于 3个胚层的多种细胞。这种特性在世界范围内掀起了对人胚胎干细胞的研究热潮 ,并取得了飞速发展。本文就人胚胎干细胞建系及体外培养分化的研究进展作一综述。
作者 陈红 钱坤 张苏明 朱桂金
机构地区 华中科技大学同济医院神经科 华中科技大学同济医院生殖中心
出处 《生殖医学杂志》 CAS 2004年第6期373-376,共4页 Journal of Reproductive Medicine
关键词 人胚胎干细胞 研究进展 体外诱导分化 正常 染色体核型 体外培养 增殖 建系 内细胞团 囊胚
分类号 R329 [医药卫生—人体解剖和组织胚胎学] Q813 [生物学—生物工程]
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参考文献24

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同被引文献28

  • 1吴红霞,李永青,吴秀山.脊椎动物心脏形态发育的转录调控[J].生命科学研究,2002,6(S2):101-105. 被引量：56
  • 2赵惠卿,朱玲玲,赵彤,吴丽颖,李海生,丁爱石,范明.低氧对胚胎干细胞增殖的影响[J].中国应用生理学杂志,2004,20(3):209-213. 被引量：8
  • 3张军强,李红霞.胚胎干细胞研究进展[J].国外医学（妇产科学分册）,2004,31(5):277-280. 被引量：4
  • 4杨鹏飞,丛笑倩,程启康,华泽钊,吴春芳,曹谊林.人胚胎干细胞程序降温保存的实验研究[J].实验生物学报,2005,38(3):247-256. 被引量：4
  • 5Fong CY,Peh GS, Gauthaman K, et al. Separation of SSEA-4 and TRA-1-60 labelled undifferentiated human embryonic stem cells from a heterogeneous cell population using magnetic-activated cell sorting(MACS)and fluorescence-activated cell sorting(FACS)[J]. Stem Cell Rev Rep,2009,5(1):72-80.
  • 6Nayernia K, Nolte J, Michetmann HW, etal. In vitro-differentiated embryonic stem cells give rise to male gametes that can generate offspring mice[J]. Dev Cell, 2006 , 11 ( 1 ) : 125-132.
  • 7Matin MM, Walsh JR, Gokhale PJ, et al. Specific knockdown of Oct4 and beta2-microglobulin expression by RNA interference in human embryonic stem cells and embryonic carcinoma cells[J]. Stem Cells,2004,22(5) :659-668.
  • 8Sumi T, Fujinuto Y, Nakatsuji N, et al. STAT3 is dispensable for maintenance of self-renewal in nonhuman primate embryonic stem cells[J], stem Cells,2004,22(5) :861-872.
  • 9Daheron I., Opitz Sir, Zeehres H, et al. LIF/STAT3 signaling fails to maintain self-renewal of human embryonic stem cells[J]. Stem Cells, 2004 ,22 (5): 770-778.
  • 10Murakami M, Ichisaka T, Maeda M, et al. mTOR is essential for growth and proliferation in early mouse embryos and embryonie stem cells[J]. Mol Cell Biol, 2004,24(15): 6710-6718.

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生殖医学杂志
2004年 第6期

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