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心肌细胞钙火花 被引量：4

Ca^(2+) sparks in cardiac myocytes
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摘要 心肌细胞钙火花是肌浆网上一个或几个成簇状分布的RyR所产生的局部钙释放,可通过单个L 型钙通道开放所触发或自发发放。钙火花呈随机发放,出现在Z线附近,其动力学特征受多种因素的调节。此外,T 型钙电流、Na+ /Ca2+交换、ICa(TTX)和IP3 等也是钙火花触发的来源。 In cardiac myocytes, Ca 2+ sparks origining fr om a single RyR or a few RyRs are triggered by a single L-type Ca 2+ channel or occur spontaneously. Ca 2+ sparks constitute the elementary local Ca 2+ release events from the SR. Ca 2+ sparks occur at Z-lines and rando mly distribute at different locations, the characteristics of the kinetics are r egulated by many factors. In addition, I Ca.T, Na+/Ca 2+ exchang e, I Ca(TTX) and IP 3 are other putative sources of Ca 2+ that tr igger SR Ca 2+ release.
作者 张广钦 程和平
机构地区 中国药科大学药理学研究室 北京大学生物膜与膜生物工程国家重点实验室
出处 《中国药理学通报》 CAS CSCD 北大核心 2005年第1期23-26,共4页 Chinese Pharmacological Bulletin
基金 国家重点基础研究发展规划资助课题(NoG2000057002)
关键词 钙火花 心肌细胞 Ca 2+ sparks cardiac myocytes
分类号 R-05 [医药卫生] R322.11 [医药卫生—人体解剖和组织胚胎学]
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参考文献25

  • 1张广钦,付昱,阳冬梅,郝雪梅,白淑华,汤依群,E.G.Lakatta,程和平.L型Ca^(2+)通道自发激活对静息心肌细胞钙火花的影响[J].中国科学（C辑）,2003,33(5):468-472. 被引量：1
  • 2Bridge JH, Ershler PR, Cannell MB. Properties of Ca2+ sparks evoked by action potentials in mouse ventricular myocytes [ J ]. J Physiol, 1999,518 ( Pt 2):469-78.
  • 3Wang SQ, Song LS, Lakatta EG et al. Ca2+ signalling between single L-type Ca2 + channels and ryanodine receptors in heart cells[J]. Nat 2001,410(6828) : 592-6.
  • 4Marx SO, Gaburjakova J, Gaburjakova M et al. Coupled gating between cardiac calcium release channels (ryanodine receptors )[J]. Circ Res, 2001,88( 11 ) :1151 -8.
  • 5Lew WY, Hryshko LV, Bers DM. Dihydropyridine receptors are primarily functional L-type calcium channels in rabbit ventricular myocytes[J]. Circ Res, 1991,69(4) :1139 -45.
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  • 7Ritter M, Su Z, Spitzer KW et al. Caffeine-induced Ca2+ sparks in mouse ventricular myncytes[J]. Am J Physiol, 2000,278(2) :666-9.
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二级参考文献12

  • 1Cheng H, Lederer W J, Cannell M B. Ca^2+ sparks: elementary events underlying excitation-contraction coupling in heart muscle. Science, 1993,262(5134): 740-744.
  • 2Cleeman L, Wang W, Morad M. Two dimensional confocal images of organization, density and gating of focal Ca^2+ release sites in rat crdiac myocytes. Proc Nail Acad Sci USA. 1998.95(18): 10984 -10989.
  • 3Lopez-Lopez J R, Shacklock P S, Balke C W, et al. Local Ca^2+ transients triggered by single L-type Ca^2+-channel currents in cardiac cells. Science, 1995, 268(5213): 1042-1045.
  • 4Cannell M B, Cheng H, Lederer W J. Control of Ca^2+ release from sarcoplasmic reticulum. Science, 1995, 268(5213): 1045-1049.
  • 5Santana L F, Gomez A M, Cheng H, et al. Relationship between sarcolemmal Ca^2+ current and Ca^2+ sparks and local control theories for cardiac excitation-contraction coupling. Circ Res, 1996. 78(1): 166-171.
  • 6Wang S Q, Song L S, Lakatta E G, et al. Ca^2+: signalling between single L-type Ca channels and ryanodine receptors in heart cells. Nature, 2001,410(6828): 592,-596.
  • 7Cannell M B, Cheng H, Lederer W J. Spatial non-uniformities in [Ca^2+]t during excitation-contraction coupling in cardiac myocytes. Biophys J, 1994, 67(5): 1942-1956.
  • 8Cheng H, Song L S, Shirokova N, et al. Amplitude distribution of calcium sparks in confocal images: theory and studies with an automatic detection method. Biophys J, 1999, 76(2): 606-617.
  • 9Cheng H, Lederer M R, Cannell M B, et al. Calcium sparks and [Ca^2+] waves in cardiac myocytes. Am J Physiol, 1996,270(1): C148-159.
  • 10Carl S L, Felix K, Caswell A H, et al. Immunolocalization of sarcolemmal dihydropyridine receptor and sarcoplasmic reticular triadin and ryanodine receptor in rabbit ventricle and atrium. J Cell Biol, 1995. 129(3):672--682.

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中国药理学通报
2005年 第1期

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