摘要
目的:观察艾迪注射液对食管鳞状细胞癌患者区域淋巴结微转移的影响。方法:按齐同原则纳入病例随机分为实验组和对照组。实验组术前给予艾迪注射液,对照组常规准备。术中均按标准术式行食管癌根治,区域淋巴结清除术。术后完成HE染色常规病理检查后,以SP免疫组化法CK(AE1/AE3)和CK10/13作为指标检测淋巴结微转移。结果:实验组15例患者共318枚淋巴结,常规病检转移阴性者211枚,其中2例(1333%)共6枚(284%)淋巴结微转移阳性表达;对照组20例患者共396枚淋巴结,常规病检转移阴性者263枚,其中10例(50%)共29枚(1103%)淋巴结微转移阳性表达。两组比较χ2=114633,P=00007。结论:艾迪注射液能有效地降低食管鳞状细胞癌区域淋巴结微转移的检出率,表明其有阻断该肿瘤细胞淋巴结微转移的作用。
OBJECTIVE:To study the change of esophageal squamous carcinoma (ESC) micrometastasis in regional lymph nodes (LN) by application of aidi injection.METHODS:Based on the principle of the homogeneity the patients randomly divided into two groups: the experiment group and the control group. The experiment group gave Aidi Injection before operation while the control group gave routine preparation. Two groups both undergone standard technique of radical esophagectomy and regional lymphadectomy. After finished the routine pathology of he staining. we used CK(AE1/AE3) and CK 10/13 to detect the micrometastasis in lymph nodes through SP immunohistochemical.RESUITS:There were 318 LNS in 15 patients in experiment group. And 211 LNS were negative in routine pathology methods while 6 LNS (2.84%) in 2 patents (13.33%) were positive in LNS micrometastasis. And there were 396 LNS in 20 patients in the control group. 263 LNS were negative in pathology method. Among them 29 LNS (11.03%) in 10 patients (50%) presented micrometastasis in LNS. There were significant difference between the two group, P=0.000 7.CONCLUSION:Aidi injection can effectively reduce the detection rate of micrometastasis in radical LNS in ESC. So it indicate that Aidi Iinjection can inhibit the function of the lymph nodes micrometastasis of the tumor cell. Chin J Cancer Prev Treat,2005,12(2):105-106
出处
《肿瘤防治杂志》
2005年第2期105-106,共2页
China Journal of Cancer Prevention and Treatment
关键词
艾迪注射液
食管鳞状细胞癌
淋巴结微转移
免疫组织化学
角蛋白
aidi injection
esophageal squamous cell carcinoma
micrometasatasis in lymph nodes
immunohistochemistry
keratin
