摘要
研究目的 探讨新生儿硬肿症并发肺出血的临床特点和防治。 研究方法 新生儿硬肿症并发肺出血患儿41例。用凝固法测定血浆凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)和纤维蛋白原(Fg)定量,用APTT方法测定血浆凝血因子Ⅷ(Ⅷ:c),用发色底物方法测定血浆抗凝血酶Ⅲ(ATⅢ:a)活性。 研究结果 硬肿症合并肺出血患者和无出血患者PT分别为27.2±7.4s和17.7±4.8s(P<0.01);APTT分别为65.8±27.8s和60.9v35.8s(P>0.05);Fg分别为165±43.9mg％和177.5±104.1mg％(P>0.05);FⅧ:c分别为28.9± 8.7％和 43.9± 11.4％(P<0.01);ATⅢ:a分别为24.3±7.9％和47.5±19.0％(P<0.01)。 结论 新生儿硬肿症并发肺出血发病者多为早产儿和低体重儿。新生儿硬肿症合并肺出血患者较无出血患者PT明显延长,而FⅧ:c和ATⅢ:a明显降低。
Objective To search for the clinical character. prevention and therapy of complicated pneumorrhagiascleredema neonatorum. Methods There are 41 cases of scleredema neonatorum combined with pneumorrhagia. The plasma pro- thrombin time (PT), activated partial thromboplastin time (APTT) and fibrinogen (Fg) were determinedby coagulation reaction, coagulation factor Ⅷ (FⅧ, c) and antithrombin Ⅲ (ATⅢ: a) were determinedby APTT and colorsubstrate methods respectively. Results In the scleredema neonatorum patients with and without pneumorrhagia, the content of plasmaPT is 27.2±7.4vsand17.7±4.8s (P<0.01),APTT: 65.8±27.8 vs 60.9±35.8s (P>0.05), Fg: 165.3±43.9vs 177.5±104.1mg/dl (P>0.05), FⅧ, c: 28.9±8.7 vs 43.9±11.4 per cent (P<0.01), ATⅢ: a: 24.3±7.9 vs 47.5±19.0 per cent (P<0.01). Conclusions Scleredema neonatorum ofter occurs in premature infants and Low birth weight newborns.scleredema neonatorum with pneumorrhagia patients' PT is obviously Longer and the FⅧ: c andATⅢ: aactivity is obviously Lower that in the patients without pneumorrhagia.
出处
《实用儿科临床杂志》
CAS
CSCD
1993年第3期154-156,共3页
Journal of Applied Clinical Pediatrics
关键词
新生儿硬肿症
肺出血
并发症
scleredema neonatorum
pneumorrhagia
premature infant
low birth weight newborn
coagulation factor
