摘要
目的 研究浙江地区白癜风患者的家系遗传特征。方法 以先证者为核心 ,回顾性调查其家系成员白癜风患病情况 ,填写调查表 ,对有家族史者绘制家系图谱。结果 在 2 473例白癜风先症者中 ,有遗传家族史者 2 86例 ,遗传率 11.6%。 2 86个家系中绝大多数均符合常染色体显性遗传特点 ,个别符合常染色体隐性遗传 ,未见性联遗传模式。结论 白癜风的家系遗传以常染色体显性遗传为主。
Objective To identify the genetic features of
vitilligo families in Zhejiang.
Methods The family genetic data were gain from the vitili
go pobands. The questionnaires and pedigree tree were made based on these data.
Results In 2 473 vitiligo probands, 286 had family histo
ries,with a heritability rate of 11.6 %. The features of autosomal dominant inh
eritance were identified in most of the 286 families,with few of autosomal reces
sive inheritance but no X or Ylinked inheritance found.
Conclusion The mainly inheritance pattern of vitilligo is
autosomal dominant.
出处
《中国皮肤性病学杂志》
CAS
北大核心
2004年第12期723-724,共2页
The Chinese Journal of Dermatovenereology
基金
浙江省教育厅基金资助 (2 0 0 1 0 0 4 9)
关键词
白癜风
系谱分析
Vitiligo
Pedigree analysis
