摘要
目的 :探讨雷公藤多甙所致药源性再生障碍性贫血的发病机制。方法 :对 3例服用雷公藤多甙导致再生障碍性贫血患者的临床资料进行分析 ,并结合文献复习。结果 :雷公藤多甙所致药源性再障均为急性发病 ,服药与起病之间关系不定 ,服药剂量与再障的发生无明显相关性 ;为可逆性骨髓造血功能衰竭。结论 :雷公藤多甙可引起服药者发生异常免疫反应 ,损伤造血干 (祖 )细胞 。
Objective:To investigate the pathogenesis of aplastic anemia induced by drug.Method:Three cases of aplastic anemia induced by multiglycosidore triptergii were analyzed their symptoms, signs, laboratory finds, treatment, histopathological features and literatines were reviewed.Result:The aplastic anemia induced by multiglycosidore triptergii occur acutely. The association between the time had the drug and its occurring is uncertain. Whether it occurs doesn't depend on the taken dosage. The bone marrow failare can recover after stopping the drug.Conclusion:Aplastic anemia induced by multiglycosidore triptergii may results from immunologically mediated, tissue-specific organ destruction.
出处
《临床血液学杂志》
CAS
2005年第1期42-44,共3页
Journal of Clinical Hematology
