3Markwardt F. The development of hirudin as an antithrombotic drug [J]. Thrornb Res, 1994, 74(1) : 1-23.
4Jiang S Y, Li G X, Han G Z. Pharmaeokinetie study with r-hirudin in rats [J]. Asian J Drug Metab Pharmacokin,2003, 3(2): 129-133.
5Tamura A, Graham P I, Mcvulloch J, et al. Fatal cerebral ischemia in the rat: description of technique and early neuropathological consequences following middle cerebral artery occlusion [J]. J Cereb Blood Flow Metab, 1981, 1 :53-56.
6Margareta E, David G, Stefan E. Antithrombotic effects and bleeding time of thrombin inhibitors and warfarin in the rats[J]. Thromb Res, 1999, 94: 187-197.
7Kurl K D, Jakubowski J A, Smith T. Antithrombotic mechanisms involved in prevention of ferric chloride-induced arterial thrombosis in rats [J]. Proc Am Soc Exp Biol, 1990, 4:A1228.
8Kawai H, Yukis H, Sugimoto J, et al. Effects of a thrombin inhibitor, argatrahan, on ischemic brain damage in the rat distal middle cerebral artery occlusion model [J]. J Pharmacol Exp Ther, 1996, 278(2): 780-785.
3del-Zoppo GJ. Microvascular changes during cerebral ischemia and reperfusion. Cerebrovasc Brain Metab Rev, 1994, 6(l ): 47-96.
4Cines DB, Pollak ES, Buck CA, et al. Endothelial cells in physiology and in the pathophysiology of vascular disorders. Blood, 1998, 91 (10): 3527-3561.
5Itoh Y, Tomita M, Tanahashi N, et al. Platelet adhesion to aortic endothelial cells in vitro after thrombin treatment: observation with video-enhanced contrast microscopy. Thromb Res, 1998, 91 (1): 15-21.
6Garcia JH, Liu KF, Yoshida Y, et al. Influx of leukocytes and platelets in an evolving brain infarct (Wistar rat). Am J Pathol. 1994, 144(1): 188-199.
7Galdiero M, de-l'Ero GC, Marcatili A. Cytokine and adhesion molecule expression in human monocytes and endothelial cells stimulated with bacterial heat shock proteins. Infect Immun, 1997, 65(2): 699-707.
8Galante A, Pietroiusti A, Silvestrini M, et al. Leukocyte and platelet aggregation in patients with ischemic stroke: a case-control study.Eur Neurol, 1993, 33(6): 442-445.
9Silvestrini M, Pietroiusti A, Magrini A, et al. Leukocyte aggregation in patients with a previous cerebral ischemic event. Stroke, 1994, 25(7): 1390-1392.