摘要
目的 :分析影响乳腺癌肝肺转移患者的预后因素。方法 :本文统计自 1996年 1月～ 2 0 0 2年 12月期间复旦大学附属肿瘤医院收治的 14 1例乳腺癌肝肺转移住院患者的治疗结果 ,分析影响乳腺癌肝肺转移患者的预后因素。结果 :一线、二线、三线和四线化疗的疗效依此下降 ,分别为 35 .6 %、30 .6 %、2 8.6 %和 12 .5 %。单因素分析和Cox多因素分析模型分析结果均提示激素受体状态、从手术到发生内脏转移时间、化疗疗效是影响生存率的独立预后因素。结论 :晚期乳腺癌化疗疗效随着使用方案次数的增多而减效。激素受体、从手术到发生内脏转移时间、化疗结果是影响乳腺癌内脏转移患者的独立的预后因素。
Objective:To investigate the prognostic fac tors for breast cancer patients with liver or lung involvement. Metho d s: 141 breast cancer patients with liver or lung metastases, who were hospitalized in Fudan University Cancer Hospital between January, 1996 and Decem ber,2002,were included in this study. Their survival data were analyzed. Results: The response rates with first-line,second-line,third-line , fourth-line chemotherapy were 35.6%、30.6%、28.6% and 12.5%,respectively. Both monovariate and multivariate analyses suggested that hormone receptor status, in terval between operation and diagnosis of metastatic breast cancer with liver or lung involvement, and chemotherapy outcome were independent prognostic factors for overall survival. Conclusion: The response rates of ch em otherapy drop with number of lines of chemotherapy. Prognostic factors for breas t cancer patients with liver or lung involvement include hormone receptor status , interval between operation and diagnosis of liver or lung involvement, and ch emotherapy outcome.
出处
《中国临床医学》
2004年第6期1037-1039,共3页
Chinese Journal of Clinical Medicine
