摘要
于治疗前后对十二指肠溃疡(DU)病人74例(男46例,女28例.平均年龄40.5±21.5)。均经胃镜胃粘膜活检幽门螺旋菌(HP)培养、血清抗 HP 抗体、病理组织学染色检查 HP、血清胃泌素检查.结果表明;①HP 感染者抗 HPIgG 滴度及血清胃泌素水平明显增高.②抗菌治疗清除 HP 后,血清胃泌素及抗 HP 抗体滴度均有明显下降.提示 HP 感染致病与血清胃泌素释放增加有关,联合应用血清胃泌素检查和 HP 血清学检查可以作为胃镜检查前 HP 感染病例筛选和治疗后 HP 清除的客观指标。
The multiple approaches to determine HP infection were studied before and after the treatment of duodenal ulcer(DU).The approaches included the culture of HP in antral biop- sies;the Giemsa staining of histological sections;urease test and serum anti-HP IgG antibo- dies measurement with and ELISA technique;the serium gastrin(RIA) was simultaneously controled.The results show that there was significnat rise in anti-HP IgG titre and level of serum gastrin,and after the clearance of HP,the level of serum gastrin and anti-HP antibody titres significantly decreased.The results supported the hypothesis that HP infection causes DU as well as the increase of serum gastrin release.Both serology and the gastrin measure- ment may be helpful in assessmont of the effect of clinical treatment and epidenilogical stud- ies.
关键词
十二指肠溃疡
幽门螺杆菌
胃泌素
duodenal ulcer
helicobacter pylori
serium gastrin
Ig antibody
