摘要
目的 评价血清白介素 18(IL 18)水平与急性冠状动脉综合征的关系及其临床意义。方法 2 0 0 3年 6月至2 0 0 4年 1月入选本院心脏科门诊和住院患者 88例 ,其中冠心病患者 70例 ,非冠心病者 18例 ,分为急性心肌梗死(AMI)组、不稳定型心绞痛 (UAP)组、稳定型心绞痛 (SAP)组及对照组。采用ELISA法测定IL 18,放射免疫平衡竞争法检测白介素 6 (IL 6 )。应用SPSS11.0进行统计分析 ,P <0 .0 5为具有统计学差异。结果 血清IL 18,6在AMI组和UAP组显著高于SAP组和对照组 (P <0 .0 1) ;血清IL 6水平在AMI组、UAP组和SAP组之间均具有显著差异 (P<0 .0 1) ;相关性分析显示IL 18,6与射血分数 (EF)均呈显著负相关 (IL 6 ,r=- 0 .70 7,P <0 .0 1;IL 18,r =- 0 .717,P <0 .0 1) ,IL 18与IL 6呈显著正相关 (r=- 0 .92 0 ,P <0 .0 1)。结论 IL 18可以反映动脉粥样硬化斑块的严重程度和稳定性状态 ,可作为监测病情的临床生化指标 ,推测其与IL 6、EF可同作为冠心病心血管事件的预测因子。
Objective To study the relations between the level of serum interleukin-18(IL-18) and acute coronary syndrome(ACS) and its clinical significance. Methods 26 patients with AMI, 23 patients with UAP, 21 patients with stable angina pectoris(SAP), and 18 health persons were studied. The concentration of serum interleukin-6(IL-6) was measured with radioimmunoassay, while Interleukin-18 with ELISA. Results The levels of sereum IL-6,18 in patients with ACS were significantly higher than that with SAP and health persons respectively and also were excellent negative linear correlation with EF. And IL-18 was pretty positive linear correlation with IL-6. Conclusion The concentration of serum IL-18 like IL-6 can reflect the severity and unstable status of the plague. So it can be clinically applied to monitor that with IL-6. Because IL-18 has excellent correlation with EF and IL-6,it can become one of the predictors of cardiovascular events with IL-6 and EF.
出处
《中国心血管杂志》
2005年第1期17-19,共3页
Chinese Journal of Cardiovascular Medicine
基金
天津市科委 2 0 0 3年度资助重点项目 (编号 :0 3 3 1113 11)
