摘要
目的 分析Survivin蛋白在膀胱移行细胞癌 (TCC)组织中的表达 ,探讨其潜在的临床意义。方法 用免疫组织化学SP法检测 75例膀胱TCC患者的肿瘤组织和 7份正常膀胱黏膜组织中Survivin蛋白的表达。结果 在 75例膀胱TCC患者的肿瘤组织中 ,有 5 8例Survivin蛋白表达阳性 ,阳性率为 77 3% ;而在 7份正常膀胱黏膜组织中Survivin蛋白均未表达。Survivin蛋白的表达与膀胱TCC的组织学分级密切相关 (P <0 0 5 )而与临床分期则无明显的相关性 (P >0 0 5 )。结论 凋亡抑制蛋白Survivin在膀胱TCC患者的肿瘤组织中过度表达 ,提示Survivin基因在膀胱TCC的发生发展中可能起重要作用 ;Survivin蛋白的表达与膀胱TCC的组织学分级有明显的相关性 ,可能成为膀胱TCC不良预后的指标之一。
Objective Survivin is a member of the inhibitors of apoptosis protein (IAP) family Recent researches had shown that survivin plays an important role in oncogenesis This study was designed to investigate the expression of survivin in transitional cell carcinoma (TCC) of urinary bladder and its clinical significance Methods Immunohistochemical assay was used to detect the expression of survivin in 75 cases of tumor tissue and 7 cases of normal bladder tissue Results The expression rates of survivin were 77 3%(58/75) in TCC of urinary bladder, whereas no expression of survivin was detected in the 7 cases of normal bladder tissue Conclusions Expression of survivin protein was observed in the tumor tissue derived from the patients with bladder TCC, indicating that this protein may play an important rule in carcinogenesis of human urinary bladder The expression of survivin was statistically significant associated with tumor grade Our results suggested that the expression of survivin may be considered as a prognostic factor for bladder TCC
出处
《中华医学杂志》
CAS
CSCD
北大核心
2004年第23期1977-1979,共3页
National Medical Journal of China
基金
国家自然科学基金资助项目 (3 0 170 43 2 )
北京市自然科学基金资助项目 (70 12 0 2 7)
首都医学发展科研基金资助项目(2 0 0 2 2 0 14 )
