摘要
为了比较三七普通粉和微粉的粉体学特征、水溶性浸出物含量、指标成分溶出量及溶出速度,探索三七粉碎的临界粒径,通过激光粒度分析仪和扫描电子显微镜对普通粉和微粉进行表征,测定粉体学参数休止角和堆密度,热浸法测定水溶性溶出物的含量,利用小杯溶出法进行指标成分的溶出实验,采用梯度HPLC分析人参皂苷Rg1、Rb1和三七皂苷R1的含量。结果表明:三七普通粉和微粉的粉体学特征、水溶性浸出物含量差异显著,人参皂苷Rg1、Rb1和三七皂苷R1的溶出速度微粉较快,但两者在溶出量上无显著差异。微粉化对中药的必要性应结合具体的中药进行研究,三七制备为100目的粉体在体外溶出已达到最适。
The powder characteristic, water extraction amount, extraction amount of active ingredients and dissolution rate are comparatively studied between crude powder and micronized powder to get the critical particle size of panax notoginseng. Panax notoginseng powder is characterized by laser diffraction analyzer and scanning electron microscopy, the angle of repose and bulk density is measured, the water extraction is quantified by heated Extractiong method, the active ingredients Rg1, Rb1 and R1 are detected by gradient HPLC after they released from panax notoginseng. The differences of particle characteristics and water extraction amount between crude powder and superfine are significant, the dissolution rate of active ingredients Rg1, Rb1 and R1 are faster, and the dissolution amount are almost the same. Micronization technology is applied or not to the Chinese traditional medicine according to study, 100 mesh is the optimal size of panax notoginseng.
出处
《中国粉体技术》
CAS
2004年第6期28-30,共3页
China Powder Science and Technology
基金
广东省人事厅博士后基金资助项目
编号:2003816。
关键词
超细粉碎
中药
三七
micronization
panax notoginseng
the Chinese traditional medicine
