期刊文献+

猪肝金属硫蛋白的诱导效果 被引量:10

Effects of inducement on metallothionein in liver of pig
下载PDF
导出
摘要 用ZnSO4经腹腔注射诱导,比较研究了不同诱导次数和剂量对猪肝金属硫蛋白的合成量的影响。结果表明:经5次锌的总剂量为330mg/kg体重诱导,金属硫蛋白的合成量显著高于3次锌的总剂量为80mg/kg体重诱导的合成量(P<0.05),但与诱导7次,锌总剂量为780mg/kg体重比合成量差异不显著。 Zinc from zinc sulfate was used as a revulsant and injected into abdomen to compare the effects of different zinc dosages and different revulsive times on synthesization of metallothionein in liver of pigs.The results showed that synthetical metallothionein in liver of the pigs treated with five celiac injections and with a 330 mg/kg zinc dosage was higher significant (P<0.05) than that with three celiac injections and with a 80 mg/kg zinc dosage. However, there was no significant difference (P>0.05) between the treatment with five celiac injections (330 mg/kg zinc dosage) and the treatment with seven celiac injections (780 mg/kg zinc dosage). 
出处 《广西农业生物科学》 CSCD 2004年第4期270-273,共4页 Journal of Guangxi Agricultural and Biological Science
基金 国家自然科学基金资助项目(30170684) 湖南省自然科学基金资助项目(01JJYZ2032)
关键词 金属硫蛋白 诱导 猪肝 metallothionein inducement liver of pig
  • 相关文献

参考文献3

二级参考文献19

  • 1任宏伟,王文清,茹炳根,李令媛,潘爱华,王英彦.鲫鱼金属硫蛋白的提纯及性质研究[J].生物化学与生物物理进展,1993,20(4):281-285. 被引量:13
  • 2Vasconcelos MH,Tam SC,Hesketh JE,et al.Metal- and tissue-dependent relationship between metallothionein mRNA and protein[J].Toxicol Appl Pharmacol,2002,182(2):91-97.
  • 3Coogan TP,Shiraishi N,Waalkes MP.Minimal basal activity and lack of metal-induced activation of themetallothionein gene correlates with lobe-specific sensitivity to the carcinogenic effects of cadmium in the rat prostate[J].Toxicol Appl Pharmacol,1995,132(1):164-173.
  • 4Shiraishi N,Barter R,Uno H,et al.Effect of progesterone pretreatment on cadmium toxicity in the male Fisher(F344/NCr) rat[J].Toxicol Appl Pharmacol,1993(b),118(1):113-118.
  • 5Liu J,Corton C,Dix DJ,et al.Genetic background but not metallothionein phenotype dictes sensitivity to cadmium-induced testicular injury in mice[J].Toxicol Appl Pharmacol,2001,176(1):1-9.
  • 6Valverde M,Fortoul TI,Diaz-Barriga F,et al.Induction of genotoxicity by cadmium chloride inhalation in several organs of CD-1 mice[J].Mutagenesis,2000,15(2):109-114.
  • 7Welsh MJ,Wiebe JP.Rat sertoli cells: A rapid method for obtaining viable cells[J].Endocrinology,1975,96(3):618-624.
  • 8McKenna IM,Bare RM,Waalkes MP.Metallothionein gene expression in testicular interstitial cell and liver of rats treated with cadmium[J].Toxicology,1996,107(2):121-130.
  • 9Ruitenberg EJ,Steerenberg PA,Brosi BJM,et al.Reliability of the enzyme-linked immunosorbent assay (ELISA) for the serodiagnosis of Trichinella spiralis infections in conventionally raised pigs[J].J Immunol Methods,1976,10(1):67-83.
  • 10Waalkes MP,Klaassen CD.Concentration of metallothionein in major organs of rats after administration of various metals[J].Fundam Appl Toxicol,1985,5(3):473-477.

共引文献20

同被引文献214

引证文献10

二级引证文献51

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部