摘要
采用反相高效液相色谱法测定了正常人单剂量口服川芎单煎剂后体内阿魏酸(FA)的经时浓度。汤剂中 FA 含量为0.7895±0.0090mg/g(川芎生药量),给药剂量为1g(川芎生药量)/kg,药代动力学参数值为:Ka=0.0912±0.0494/min;Ke=0.0605±0.0118/min;t_(1/2)(Ka)=7.6028±1.0736min;t_(1/2)(Ke)=11.4604±3.2316min;T(peak)=17.7491±1.1418min;C(max)=334.6694±58.8826ng/ml;AUC=12423.6211±4446.6597(ng/ml)min;CL/F(s)=0.0036±0.0013mg/min(ng/ml);V/F(c)=0.0586±0.0183mg/(ng/ml)。结果表明 FA 的体内分布和代谢符合单室模型。
We studied the pharmacokinetics of ferulie acid(FA)in healthy after administering a single dose(lg/kg)of clinical decoction of Ligusticum chunanxiong Hort(LCH)by RP-HPLC.FA in serum of six healthy volun- teers are detected at 320nm.The contents of FA in clinical decoction of LCH is 0.7895±0.0090mg/g(LCH). Important Pharmacokinetic parameters are as follows;Ka=0.0912±0.0494 min^(-1);Ke=0.0605±0.0118 min^(-1);t_(1/2)(Ka)=7.6028±1.0736 min;t_(1/2)(Ke)=11.4604±3.2316 min;T(peak)=17.7491±1.1418 min;C (max)=334.6694±58.8826 ng/ml;AUC=12423.6211±4446.6597(ng/ml)min.CL/F(s)=0.0036±0. 0013 mg/min(ng/ml);V/F(c)=0.0586±0.0183mg/(ng/ml).Pharmacokinetics of FA in healthy is consis- tent with One-compartment Model.
出处
《中药药理与临床》
CAS
CSCD
1996年第6期38-40,共3页
Pharmacology and Clinics of Chinese Materia Medica
基金
国家自然科学基金No 39570870
