摘要
目的探讨内皮素(ET)和降钙素基因相关肽(CGRP)在新生儿缺氧缺血性脑病(HIE)中的变化及临床意义。方法采用放射免疫法对36例HIE患儿和18例健康足月新生儿血浆ET和CGRP水平进行了同期动态测定。结果HIE患儿急性期血浆ET和CGRP水平较恢复期明显增高(P<0.01),并明显高于同期对照组水平(P<0.01),恢复期与正常对照组无显著性差异。急性期不同程度HIE及对照组之间ET,CGRP水平比较表明,重度组明显高于对照组、轻度组及中度组,中度组高于对照组和轻度组,轻度组与对照组无显著性差异。急性期患儿血浆ET和CGRP呈直线正相关(r=0.38,P<0.05)。结论ET和CGRP参与了新生儿缺氧缺血性脑病的病理生理过程。ET的增高可能是促发HIE脑损伤的一个重要因素,而CGRP增高在HIE病程中对脑损伤可能具有一定保护作用。
Objective To study the changes of plasma endothelin (ET) and calcitoningene related peptide (CGRP) levels and their clinical implication in neonates with hypoxic-ischemic encephalopathy (HIE). Methods Dynamic variations of plasma ET and CGRP levels were measured in 36 neonates with HIE and 18 normal neonates by radioimmunoassay method. Results Plasma ET and CGRP levels markedly increased in the acute stage of HIE, especially of severe and moderate groups. ET and CGRP levels in newborn infants with HIE were reduced to normal levels in the convalescence stage. There was a positive correlation between plasma ET and CGRP levels at acute stage of HIE neonates. Conclusions ET and CGRP might be involved in the pathophysiologic process of HIE,CGRP may be play a protective role in HIE.
出处
《中国当代儿科杂志》
CAS
CSCD
1999年第3期129-131,共3页
Chinese Journal of Contemporary Pediatrics