摘要
目的 探讨小儿中枢神经系统(CNS) 疾病脑脊液(CSF) 和血清髓鞘碱性蛋白( MBP) 水平的改变及临床意义,寻找反映小儿CNS损伤的生化指标。方法 证实为CNS疾病的患儿85 例,其中男58 例,女27 例,年龄1 月~13 岁。采用ELISA 法对病例血清及部分病例CSF标本作MBP定量测定。结果 疾病组中CNS感染、颅内出血、及颅内占位性病变等病例中CSF和血清MBP均值都明显高于正常对照组。结论 任何原因导致CNS髓鞘结构的破坏时,其MBP在CSF的水平升高,当血清MBP含量也升高时,提示血脑屏障(BBB) 破坏,通透性升高。结果显示对CSF和血清MBP的检测,可作为一项反映CNS损伤的生化指标。
Objective To investigate the change of myelin basic protein (MBP) in serum and CSF in children with central nervous system (CNS) diseases and its clinic significance, and to find a biochemistry index for CNS damage.Methods The ELISA method was used to determine the level of MBP in the serum and CSF of 85 cases of CNS diseases (58 males and 27 females, 1m~13y in age), including CNS infection, convalescence of HIE, delayed Vitmine K deficiency-induced intracranial hemorrhage, febrile convulsion and CNS tumor.Results Both means of MBP in serum and CSF were apparently higher in the CNS diseases group those of the control group. Conclusions There are different degree increase of MBP in serum and CSF in different CNS diseases, indicating a demyelinating pathological course and injurg of blood-brain barrier. The level of MBP in serum and CSF may taken as a biochemical index of reflecting CNS injury.
出处
《中国当代儿科杂志》
CAS
CSCD
1999年第4期202-203,共2页
Chinese Journal of Contemporary Pediatrics