摘要
目的:观察生脉注射液对2型糖尿病肾病患者血液细胞因子的影响,探讨生脉注射液治疗2型糖尿病肾病的机制。方法:2000-03/2003-06永州市人民医院内分泌科住院2型糖尿病肾病患者56例。按随机数字法将患者分为治疗组和对照组,各28例。选择30例本院健康体检自愿者作为对照组。治疗组给予生脉注射液治疗,对照组予常规西药治疗,于治疗前后检测患者血液中细胞因子白细胞介素6(IL-6)、肿瘤坏死因子-α(TNF-α)水平并与正常组进行比较。结果:生脉注射液治疗2型糖尿病肾病总有效率75%,而对照组总有效率为43%,两组比较,差异有显著性意义(χ2=5.976,P=0.028)。2型糖尿病肾病患者TNF-α和IL-6水平明显高于正常组(t=17.56,18.15,P<0.01)。治疗前生脉注射液治疗组血液中TNF-α犤(245.88±29.93)ng/L犦和IL-6犤(213.45±32.76)ng/L犦水平与对照组血液中TNF-α犤(257.43±27.65)ng/L〗和IL-6犤(203.87±34.15)ng/L犦比较,差异无显著性意义(P>0.05);治疗后生脉注射液治疗组血液中TNF-α犤(197.52±25.67)ng/L犦和IL-6犤(145.83±26.67)ng/L犦显著低于对照组血液中TNF-α犤(243.76±28.52)ng/L犦和IL-6犤(184.26±29.61)ng/L〗水平(t=6.377,5.103,P均<0.01)。生脉注射液治疗组治疗后尿蛋白量犤(1.15±0.58)g/24h犦显著低于对?
AIM:To observe the effect of shengmai parenteral solution on hemal cytokine in the patients with 2 type diabetic nephropathy and study the curing mechanism of shengmai parenteral solution to diabetic nephropathy. METHODS:From March 2000 to June 2003,totally 56 patients with 2 type diabetic nephropathy were selected from the Department of Endocrinology,People's Hospital of Yongzhou.They were randomly divided into treatment group(28 cases) and control group(28 cases).Thirty cases of healthy volunteers were selected as normal group.The treatment group was treated with shengmai parenteral solution.The control group was treated with western medicine routinely.The levels of tumor necrosis factor-alpha(TNF-α) and interleukin-6(IL-6) in the blood of patients were tested both before and after the treatment and compared with the normal group. RESULTS:The total effective rate(75%) of shengmai parenteral solution to diabetic nephropathy was significantly higher than that of control group(42.9%).There was significant difference(χ2=5.976, P=0.028).The levels of TNF-αand IL-6 in patients with 2 type diabetic nephropathy were significantly higher than those of normal group(t=17.56,18.15,P< 0.01). There was no significant difference of TNF-αand IL-6 between the shengmai parenteral solution treated group[TNF-α:(245.88±29.93) ng/L,IL-6:(213.45±32.76) ng/L] and the control group [TNF-α:(257.43 ±27.65) ng/L,IL-6:(203.87±34.15) ng/L] before the treatment (P >0.05).However,the levels of TNF-α[(197.52±25.67) ng/L]and IL-6[(145.83±26.67) ng/L] in the shengmai parenteral solution treated group were lower than those of control group [TNF-α:(243.76±28.52) ng/L;IL-6: (184.26±29.61) ng/L]after treatment(t=6.377,5.103,P< 0.01).And after treatment,the urine protein of Shengmai parenteral solution treated group[(1.15±0.58)g per 24 hours] was significantly lower than that of control group [(1.46±0.64)g per 24 hours](t =1.899,P< 0.000 1). The urine protein in shengmai parenteral solution treated group was positively correlated to TNF-αand IL-6 before and after treatment(r=0.643 2,0.753 7,0.724 6,0.685 8,P< 0.01). CONCLUSION:There is a significant treatment effect of shengmai parenteral solution on the patients with 2 type diabetic nephropathy.The curing mechanism of shengmai parenteral solution to diabetic nephropathy may relate to the role of this solution that can regulate the production of inflammatory cytokine and can inhibit inflammatory reaction.
出处
《中国临床康复》
CSCD
北大核心
2005年第3期172-174,共3页
Chinese Journal of Clinical Rehabilitation
