摘要
目的研究原发性高血压患者中,微量白蛋白尿组及非微量白蛋白尿组在临床特征及心脏结构诸指标方面的差异并探讨其临床意义.方法以60例原发性高血压患者为研究对象,停服抗高血压药物2周后,检测其晨尿白蛋白浓度(Alb)及肌酐(Cr)水平,并以彩色多普勒超声心动图检测其室间隔厚度(IVS)、左室后壁厚度(PWT)、左室舒张末期内径(LVDd),计算左室重量(LVM)及左室重量指数(LVMI).结果 42%的患者存在微量白蛋白尿(MAU)(2.5＜Alb/Cr＜25),微量白蛋白尿组(MA)患者及非微量白蛋白尿组(NA)患者在收缩压(SBP)、舒张压(DBP)、年龄、高血压病程、及血糖方面差异无显著性(P＞0.05),MA组的IVS、PWT、LVDd、LVW及LVMI皆显著高于NA组(P＜0.05～0.01).结论微量白蛋白尿可能与原发性高血压患者心脏结构的早期损害有关.
Objective To study the difference of clinical properties and microalbuminal changes between normal buminuril group and microalbuminuria group in patients with hypertension. Methods The patients with hypertension (mean age:59±8.9 years) were evaluated after two weeks of a washout period of all antihypertensive drugs, all patients underwent a determination of morning urine albumin, creatinine concentration and an echocardiographic evaluation. Results 42% of the patients presented microalbuminuria ( 2.5<Alb/Cr< 25).Compared with normoalbuminuric patients, those who had microalbuminuria presented no difference in age, BMI, duration of hypertension, systolic blood pressure(SBP), diastolic blood pressure(DPB) and serum glucose,but higher values of most cardiac parameters, such as interventricular septum thickness(IVS), left ventricular posterior wall thinckness (PWT), left ventricular end-diastolic dimension(LVDd), left ventricular mass (LVM) and left ventricular mass index (LVMI) (P<0.05-0.01). Conclusions These data indicate that microalbuminuria in essential hypertension may be related to early cardiac structural damage.
出处
《实用老年医学》
CAS
2005年第1期44-46,共3页
Practical Geriatrics
