摘要
目的 :探讨癌胚抗原 (CEA)及癌抗原 199(CA199)对肺腺癌诊断的应用价值。方法 :采用电化学发光法对 5 0例肺腺癌患者的胸腔积液、血清及 5 0例非肺腺癌患者的胸腔积液进行了免疫蛋白定量分析。结果 :肺腺癌组胸腔积液内CEA及CA199水平明显高于非肺腺癌组水平 ,P <0 0 1;肺腺癌组胸腔积液中CEA及CA199水平明显高于血清中水平 ,P <0 0 5 ;CEA与CA199联合检测为最佳组合 ,其敏感性和特异性均高达 96 0 %。结论
OBJECTIVE:To study the clinical value of carcinoembryonic antigen (CEA) and cancer antigen 199 (CA199) in the diagnosis of lung cancer.METHODS: Quantities of immunoprotein were analyzed by the electrochemoluminescence in the pleural fluid and the serum from lung adenocarcinoma (50 cases) and in the pleural fluid from non lung cancer (50 cases).RESULTS:The levels of CEA and CA199 in the pleural fluid of patients with lung adenocarcinoma were significantly higher than those in the pleural fluid of patients without lung cancer, P<0.01;the levels of CEA and CA199 in the pleural fluid were obviously higher than those in the serum of patients with lung adenocarcinoma,P<0.05.The combined assay of CEA with CA199 was optimal.Both sensitivity and specificity were 96.0%.CONCLUSIONS:The assaying of CEA and CA199 has important clinical value in the diagnosis of lung adenocarcinoma.
出处
《肿瘤防治杂志》
2004年第4期353-354,共2页
China Journal of Cancer Prevention and Treatment
基金
辽宁省教委科研项目基金 ( 2 0 2 0 13 13 4)资助
关键词
肺肿瘤
肿瘤标志物
胸腔积液
lung neoplasms
tumor markers
pleural fluid
