摘要
目的了解6年来广州地区淋球菌对5种抗生素的耐药趋势及产青霉素酶淋球菌(PPNG)和高水平耐四环素淋球菌(TRNG)的流行状况。方法用琼脂稀释法测定最低抑菌浓度(MICs)以及用纸片碘量法检测β内酰胺酶。结果719株淋球菌检出PPNG94株(131%)、TRNG119株(166%),6年来,PPNG、TRNG流行率及环丙沙星耐药率,经μ检验,P<001,差异有显著意义。头孢曲松、壮观霉素未发现耐药菌株,壮观霉素抗菌活性最强。结论壮观霉素在临床上可以作为治疗淋病的首选药物,具有良好疗效。
Objective The study was to investigate, in the past six years, the developing trends of resistance of Neisseria gonorrhoeae to 5 antibiotics and the prevalence of penicillinase producing Neisseria gonorrhoeae ( PPNG) and high level tetracycline resistant Neisseria gonorrhoeae (TRNG) MethodMinimum inhibitory concentrations(MICs) were determined by using the agar dilution method and β lactamase production was comfirmed by paper iodin quantitative method Results Among 719 strains, 94 strains (13 1%) were found to be PPNG and 119 strains(16 6%) were TRNG In the past six years, the prevalence rate of PPNG、TRNG and the resistant rate of ciprofloxacin showed obvious difference( P < 0 01 by u test) The strains resistant to ceftriaxone and spectinomycin were not found yet The spectinomycin showed the greatest susceptibility Conclusion The study showed that it was important to successively survey the antibiotic resistance of Neisseriae gonorrhoeae
出处
《中华检验医学杂志》
CAS
CSCD
北大核心
2004年第11期761-763,共3页
Chinese Journal of Laboratory Medicine
