摘要
目的 探讨咳嗽变异型哮喘 (CVA)与慢性咳嗽病因的相关性。方法 对原因不明的慢性咳嗽患者作肺通气功能检查 ,FEV1实测值 /预计值 <80 %者行支气管舒张试验 ,FEV1实测值 /预计值≥ 80 %予气道反应性测定 ,并对咳嗽变异型哮喘与慢性咳嗽的病因进行相关性研究。结果 172例肺通气功能检查 ,FEV1实测值 /预计值 <80 %者 118例 ,支气管舒张试验阳性 37例、阴性 81例 ;FEV1实测值 /预计值≥ 80 %者 5 4例 ,接受磷酸组织胺药物吸入支气管激发试验 ,气道反应性增高者 15例 ,气道反应性正常者 39例 ;据此 ,本组病人可诊断咳嗽变异型哮喘 5 2例 ,占慢性咳嗽病因的 30 .2 % ,由此可见咳嗽变异型哮喘是慢性咳嗽的重要病因 ,咳嗽变异型哮喘与慢性咳嗽的病因密切相关。结论 咳嗽变异型哮喘是慢性咳嗽的主要病因 ,两者密切相关 ,咳嗽变异型哮喘是哮喘的前驱状态 ,可发展为典型的哮喘 ,对病因为咳嗽变异型哮喘的慢性咳嗽患者早期发现并施以正确的治疗 ,可以预防典型哮喘的发病。
Objective To explore the relations between cough-variant-asthma(CVA) and chronic cough by assay pulmonary function and airway responsiveness.Methods Pulmonary ventilation function test were performed in 172 patients with chronic cough of unknown reasons,those with obstructive dysfunction of pulmonary ventilation were treated with bronchial dilation test,and the rest with normal pulmonary ventilation function were treated with bronchial provocation test.Results One hundred and eighteen patients with obstructive dysfunction of pulmonary ventilation received bronchial dilation test,the positive cases and the negative cases are 37/118 and 81/118 respectively.54 patients with normal pulmonary ventilation function received bronchial provocation test by inhaling histamine phosphate,15 patients had high airway responsiveness,39 patients had normal.Thus 52 patients were diagnosed as CVA,they made up 30.2% of the chronic cough sufferer.Conclusion CVA is the main cause of chronic cough,their relativity is very close.CVA is premonitory condition of asthma,it can develop typical asthma.If CVA sufferers presenting symptoms of chronic cough could been made precise diagnosis at early stage and given proper treatment,typical asthma may not occur.
出处
《潍坊医学院学报》
2004年第6期408-411,共4页
Acta Academiae Medicinae Weifang
基金
安徽省淮北市政府科研基金资助项目 (淮科 [2 0 0 3 ] 2 5号 )
关键词
肺功能测定
气道反应性测定
哮喘
咳嗽变异型
咳嗽
慢性
Pulmonary function test
Cough-variant asthma
Chronic cough
Airway responsiveness test
