摘要
目的 研究2型糖尿病患者血压、血脂、糖化血红蛋白(HbA1c)、体重指数(BMI)、体重等对尿白蛋白/肌酐的影响。方法 对538名2型糖尿病患者采血、留取晨尿,分别测定其空腹血糖、血脂、HbA1c、晨尿白蛋白(Alb)、肌酐(Cr),计算Alb/Cr(mg/mmol),测量身高、体重、坐位血压。分别将患者分为高血压和非高血压组(177和361例)、肥胖和非肥胖组(181和357例)、高胆固醇组与正常胆固醇组(108和430例),分析血压、血脂、BMI、HbA1c与尿Alb/Cr的关系。结果 Alb/Cr与收缩压、体重、BMI相关(P<0 .01)。高血压者的尿Alb/Cr值为(3. 1±0 . 5)mg/mmol,正常血压患者的尿Alb/Cr值为(1. 7±0. 2)mg/mmol,二者之间的差异有统计学意义(P<0 .05 );血压高与血压正常患者的年龄为(64±5)岁与(61±5)岁、BMI为(26 .2±3 .1)与(23. 5±2. 6)、血浆总胆固醇为(6 0±1 7)mmol/L与(4 . 8±1 .5)mmol/L,差异有统计学意义(P<0 .05 )。BMI≥25者Alb/Cr值为(2. 7±0. 5)mg/mmol,BMI<25者Alb/Cr值为(1. 8±0 .5 )mg/mmol,二者差异有统计学意义;两组胆固醇(5 9±2 9)mmol/L与(4. 1±1 .5)mmol/L之间的差异有统计学意义(P<0. 05)。血浆胆固醇≥5 6mmol/L者Alb/Cr值为( 2. 4±1. 9 )mg/mmol, <5 6mmol/L者Alb/Cr值为( 2 .2±1. 3 )mg/mmol,二者?
Objectives To investigate the effects of blood pressure, lipid profile, glucosylated hemoglobin A1c (HbA1c), body mass index (BMI) and body weight on ratio of urinary levels of albumin to creatinine (Alb/Cr).Methods Totally, 538 patients with type-2 diabetes were enrolled and their blood and urine specimens were collected for measuring fasting blood glucose, lipid profile, HbA1c, urinary levels of albumin and creatinine (for calculation of ratio of Alb/Cr, mg/mmol). Their height, body weight (for calculation of BMI) and blood pressure were recorded at the same time. The relationship between Alb/Cr and blood pressure, lipid profile, BMI, HbA1c were analyzed, respectively.Results The patients could be divided into hypertensive (177 cases) and normotensive (361 cases) groups, obese (181 cases) and non-obese (357 cases) groups, and hypercholesteremia (108 cases) and normal blood cholesterol (430 cases) groups. Stepwise regression analysis showed that Alb/Cr associated with systolic blood pressure, body weight, BMI (P<0.01). Alb/Cr averaged (3.1±0.5) mg/mmol in hypertensives, significantly higher than that in normatensives (1.7±0.2) mg/mmol, (P<0.05). BMI was (26.2±3.1) and (23. 5±2.6) and plasma level of total cholesterol (TC) was (6.0±1.7) mmol/L and (4.8±1.5) mmol/L,respectively, in hypertensives aged (64±5) years and normotensives aged (61±5) years, respectively, with significant difference (P<0.05). Alb/Cr was (2.7±0.5) mg/mmol and (1.8±0.5) mg/mmol in those with BMI equal to or greater than 25 and less than 25, respectively, with significant difference (P<0.05). Plasma level of TC was (5.9±2.9) mmol/L and (4.1±1.5) mmol/L in the two groups, respectively, with significant difference (P<0.05). Alb/Cr was (2.4±1.9) mg/mmol and (2.2±1.3) mg/mmol in those with plasma level of TC equal to or greater than 5.6 mmol/L and less than 5.6 mmol/L,respectively, but not reaching significant difference (P>0.05).Conclusions Ratio of urine levels of Alb/Cr correlated to hypertension and obesity, but relationship between Alb/Cr and age, lipid profile should be further studied. Hypertension and obesity may be high risk factors for diabetic nephropathy in patients with type 2 diabetes.
出处
《中华全科医师杂志》
2005年第1期20-22,共3页
Chinese Journal of General Practitioners
