摘要
目的评价两种碳青酶烯类抗生素美罗培南、亚胺培南治疗成人急性粒细胞缺乏症的疗效及安全性。方法回顾分析31例使用美罗培南、30例使用亚胺培南治疗的成人急性粒细胞缺乏症患者的临床表现、细菌学培养结果以及不良反应,临床分离菌分别进行美罗培南、亚胺培南的体外药敏试验。结果美罗培南、亚胺培南疗效均较好,临床治疗总有效率分别是93.5%和86.7%,P>0.05;本组患者咽拭子、血、尿培养共获90株病原菌,经治疗后,美罗培南组病原菌清除率为77.6%,亚胺培南组为63.4%,P<0.01;另外,这两种药物使用中不良反应发生较少而轻。结论碳青酶烯类抗生素用于治疗成人急性粒细胞缺乏症疗效确切安全,是理想的选择。
OBJECTIVE To evalulate the efficiency and safety of two kinds of carbapenem antibiotics-meropenem, and imipenem used to treat adult acute neutropenia syndrome (AANS). METHODS The clinical behavior, ~bacteria spectrum and side-effect of thirty-one AANS cases treated with meropenem, and thirty with imipenem were retrospectively analyzed. The isolated bacteria were done ex vivo drug sensitive test with meropenem and imipenem, respectively. RESULTS The total efficiency rate: meropenem was 93.5% and imipenem was 86.7%, P>0.05. Ninety bacteria strains were obtained from the patients pharynx, blood and urine in this group, after treatment the bacteria clearance was 77.6% in meropenem and 63.4% in imipenem, P<0.01. Otherwise, these two kinds of drugs had little side-effect. CONCLUSIONS Carbapenem antibiotics used to treat AANS have ~better efficiency and are of ideal choice.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2005年第1期82-84,共3页
Chinese Journal of Nosocomiology
